Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T52297 | Target Info | |||
| Target Name | Oxysterols receptor LXR-alpha (NR1H3) | ||||
| Synonyms | Nuclear receptor subfamily 1 group H member 3; Nuclear receptor LXRalpha; Nuclear orphan receptor LXR-alpha; Liver X receptor alpha; LXRalpha; LXRA | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | NR1H3 | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Nuclear hormone receptors | [+] 3 Nuclear hormone receptors | + | |||
| Interacting Target Name | Orphan nuclear receptor SHP (NR0B2) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Affinity Capture-Western | [1] | |||
| 4 | Co-localization | [1] | |||
| Interacting Target Name | Retinoic acid receptor RXR-gamma (RXRG) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3; NR2B3 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Yeast two hybrid | [3] | |||
| 2 | Yeast two hybrid | [4] | |||
| Interacting Target Name | Retinoic acid receptor RXR-beta (RXRB) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; NR2B2 | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Yeast two hybrid | [5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes. Sci Signal. 2016 Aug 2;9(439):ra78. | ||||
| REF 2 | The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Mol Endocrinol. 2002 Sep;16(9):2065-76. | ||||
| REF 3 | Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80. | ||||
| REF 4 | Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13. | ||||
| REF 5 | Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11;164(4):805-17. | ||||
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