Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T52886 Target Info
Target Name AS1 14-3-3 protein eta (YWHAH)
Synonyms YWHA1; Protein AS1; 14-3-3 protein eta
Target Type Literature-reported Target
Gene Name YWHAH
UniProt ID
1433F_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
4 Yeast two hybrid [2]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [5]
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 7 (HDAC7) Patented-recorded Target Interacting Protein Info
UniProt ID
HDAC7_HUMAN 
Synonyms Histone deacetylase 7A; HDAC7A; HD7a; HD7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [6]
Interacting Target Name Histone deacetylase 5 (HDAC5) Patented-recorded Target Interacting Protein Info
UniProt ID
HDAC5_HUMAN 
Synonyms KIAA0600; HD5; Antigen NY-CO-9
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [7]
Ester hydrolases [+] 3 Ester hydrolases +
Interacting Target Name M-phase inducer phosphatase 2 (MPIP2) Clinical trial Target Interacting Protein Info
UniProt ID
MPIP2_HUMAN 
Synonyms Dual specificity phosphatase Cdc25B; CDC25HU2; Cdc25B phosphatase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [9]
3 Yeast two hybrid [9]
Interacting Target Name M-phase inducer phosphatase 1 (MPIP1) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP1_HUMAN 
Synonyms Dual specificity phosphatase Cdc25A; Cdc25A phosphatase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Proximity Label-MS [10]
Interacting Target Name M-phase inducer phosphatase 3 (MPIP3) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP3_HUMAN 
Synonyms Dual specificity phosphatase Cdc25C; Cdc25C phosphatase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
Kinases [+] 5 Kinases +
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [14]
4 Affinity Capture-Western [15]
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [16]
Interacting Target Name Microtubule affinity regulating kinase 3 (MARK3) Clinical trial Target Interacting Protein Info
UniProt ID
MARK3_HUMAN 
Synonyms Serine/threonine-protein kinase p78; Ser/Thr protein kinase PAR-1; Protein kinase STK10); Protein kinase STK10; Par-1a; MAP/microtubule affinity-regulating kinase 3; EMK-2; EMK2; ELKL motif kinase 2; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [17]
2 Affinity Capture-Western [18]
Interacting Protein Name Proto-oncogene A-Raf (ARAF ) Interacting Protein Interacting Protein Info
UniProt ID
ARAF_HUMAN 
Synonyms Serine/threonine-protein kinase A-Raf; Proto-oncogene Pks; Proto-oncogene A-Raf-1; Proto-oncogene A-Raf; PKS2; PKS; ARAF1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [13]
Interacting Target Name Serine/threonine-protein kinase B-raf (BRAF) Successful Target Interacting Protein Info
UniProt ID
BRAF_HUMAN 
Synonyms V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [19]
Proteins 14-3-3 [+] 2 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [5]
Interacting Protein Name 14-3-3 protein gamma (YWHAG) Interacting Protein Interacting Protein Info
UniProt ID
1433G_HUMAN 
Synonyms 14.3.3GAMMA; PPP1R170
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [5]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Yes-associated protein 1 (YAP1) Literature-reported Target Interacting Protein Info
UniProt ID
YAP1_HUMAN 
Synonyms Yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; 65 kDa Yes-associated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Proximity Label-MS [20]
References  Top
REF 1 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 2 A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem Biophys Res Commun. 1997 Sep 18;238(2):590-4.
REF 3 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J Biol Chem. 1996 Aug 16;271(33):20029-34.
REF 4 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 5 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 6 Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. Circ Res. 2010 Apr 16;106(7):1202-11.
REF 7 Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Mol Cell Proteomics. 2011 Feb;10(2):M110.004317.
REF 8 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 9 Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase. Oncogene. 2000 Mar 2;19(10):1257-65.
REF 10 Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Cell Syst. 2017 Apr 26;4(4):430-444.e5.
REF 11 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
REF 12 Involvement of protein kinase PKN1 in G2/M delay caused by arsenite. Mol Carcinog. 2005 May;43(1):1-12.
REF 13 Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein. Biochemistry. 2002 Apr 30;41(17):5566-72.
REF 14 Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell. 2005 Oct;16(10):4733-44.
REF 15 Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis. Exp Cell Res. 2001 Nov 15;271(1):142-51.
REF 16 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol. 2005 Mar;7(3):278-85.
REF 17 Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J Biol Chem. 2004 Mar 26;279(13):12804-11.
REF 18 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010 Sep 15;430(3):393-404.
REF 19 A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Dec;7(23):4228-34.
REF 20 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal. 2013 Nov 19;6(302):rs15.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.