Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T53270 Target Info
Target Name Activating transcription factor 4 (ATF-4)
Synonyms cAMPresponsive elementbinding protein 2; cAMPdependent transcription factor ATF4; cAMP-responsive element-binding protein 2; cAMP-dependent transcription factor ATF-4; Taxresponsive enhancer elementbinding protein 67; TaxREB67; Tax-responsive enhancer element-binding protein 67; TXREB; DNAbinding protein TAXREB67; DNA-binding protein TAXREB67; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMPdependent transcription factor ATF4; Cyclic AMP-responsive element-binding protein 2; Cyclic AMP-dependent transcription factor ATF-4; CREB2; CREB-2
Target Type Literature-reported Target
Gene Name ATF4
Biochemical Class Basic leucine zipper bZIP
UniProt ID
ATF4_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [1]
5 Reconstituted Complex [4]
Kinases [+] 1 Kinases +
Interacting Protein Name Tribbles homolog 3 (TRIB3) Interacting Protein Interacting Protein Info
UniProt ID
TRIB3_HUMAN 
Synonyms C20orf97; NIPK; SINK; SKIP3; TRB3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Yeast two hybrid [7]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [8]
2 Fluorescence Resonance Energy Transfer [9]
3 Reconstituted Complex [10]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [8]
2 Reconstituted Complex [11]
Interacting Target Name Proto-oncogene c-Fos (c-Fos) Literature-reported Target Interacting Protein Info
UniProt ID
FOS_HUMAN 
Synonyms Proto-oncogene c-Fos; G0S7; G0/G1 switch regulatory protein 7; C-fos; Cellular oncogene fos
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [8]
2 Fluorescence Resonance Energy Transfer [9]
Interacting Target Name Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) Literature-reported Target Interacting Protein Info
UniProt ID
ATF3_HUMAN 
Synonyms Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Fluorescence Resonance Energy Transfer [9]
Interacting Protein Name CCAAT/enhancer-binding protein epsilon (CEBPE) Interacting Protein Interacting Protein Info
UniProt ID
CEBPE_HUMAN 
Synonyms C/EBP.epsilon; CRP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [13]
2 Fluorescence Resonance Energy Transfer [9]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Yeast two hybrid [15]
Other proteins [+] 1 Other proteins +
Interacting Protein Name F-box/WD repeat-containing protein 1A (BTRC) Interacting Protein Interacting Protein Info
UniProt ID
FBW1A_HUMAN 
Synonyms BETA.TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Yeast two hybrid [17]
3 Yeast two hybrid [7]
4 Yeast two hybrid [15]
References  Top
REF 1 p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. J Biol Chem. 2005 Dec 16;280(50):41537-45.
REF 2 Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. J Biol Chem. 2007 Dec 7;282(49):35687-94.
REF 3 Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation. J Biol Chem. 2003 Feb 14;278(7):4770-7.
REF 4 Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators. Blood. 2004 Mar 15;103(6):2135-42.
REF 5 SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. Oncogene. 2003 May 8;22(18):2823-35.
REF 6 E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3. Cell Signal. 2008 May;20(5):942-8.
REF 7 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 8 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 9 Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4.
REF 10 Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3720-4.
REF 11 Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein. J Biol Chem. 1997 Sep 19;272(38):24088-95.
REF 12 ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2200-5.
REF 13 A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem J. 2007 Feb 15;402(1):163-73.
REF 14 Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53. Mol Cell. 2016 Jun 16;62(6):890-902.
REF 15 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 16 ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. Mol Cell Biol. 2001 Mar;21(6):2192-202.
REF 17 Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80.

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