Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T53524 | Target Info | |||
Target Name | Platelet-derived growth factor receptor alpha (PDGFRA) | ||||
Synonyms | RHEPDGFRA; Platelet-derived growth factor receptor 2; Platelet-derived growth factor alpha receptor; PDGFR2; PDGFR-alpha; PDGFR-2; PDGF-R-alpha; CD140a antigen; CD140a; CD140 antigen-like family member A; Alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor | ||||
Target Type | Successful Target | ||||
Gene Name | PDGFRA | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
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Acyltransferases | [+] 1 Acyltransferases | + | |||
Interacting Target Name | Signal transduction protein CBL (CBL) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Reconstituted Complex | [2] | |||
Ester hydrolases | [+] 1 Ester hydrolases | + | |||
Interacting Protein Name | Phospholipase C-gamma-1 (PLCG1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [3] | |||
2 | Affinity Capture-Western | [4] | |||
3 | Biochemical Activity | [4] | |||
4 | Co-localization | [5] | |||
Kinases | [+] 3 Kinases | + | |||
Interacting Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [6] | |||
2 | Protein-Fragment Complementation Assay | [6] | |||
3 | Yeast two hybrid | [7] | |||
Interacting Target Name | Platelet-derived growth factor receptor beta (PDGFRB) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Platelet-derived growth factor receptor 1; PDGF-R-beta; PDGFR-beta; PDGFR-1; PDGFR1; PDGFR; CD140b antigen; CD140b; CD140 antigen-like family member B; Beta-type platelet-derived growth factor receptor; Beta-PDGFR; Beta platelet-derived growth factor receptor | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [8] | |||
2 | Reconstituted Complex | [9] | |||
Interacting Protein Name | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | AGM7; GRB1; IMD36; p85; p85.ALPHA | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [10] | |||
2 | Co-localization | [5] | |||
Other proteins | [+] 1 Other proteins | + | |||
Interacting Target Name | Proto-oncogene c-Crk (c-Crk) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | P38; Adapter molecule crk | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [11] | |||
2 | Co-localization | [5] | |||
3 | Reconstituted Complex | [11] |
References | Top | ||||
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REF 1 | Loss of PRMT5 Promotes PDGFR Degradation during Oligodendrocyte Differentiation and Myelination. Dev Cell. 2018 Aug 20;46(4):426-440.e5. | ||||
REF 2 | Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity. Mol Cell Biol. 1997 Aug;17(8):4597-610. | ||||
REF 3 | Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors. J Biol Chem. 1995 Mar 31;270(13):7773-81. | ||||
REF 4 | Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell. 1993 Apr 23;73(2):321-34. | ||||
REF 5 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
REF 6 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 7 | In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84. | ||||
REF 8 | A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex. Eur J Biochem. 1994 Oct 1;225(1):29-41. | ||||
REF 9 | Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol Chem. 1989 May 25;264(15):8771-8. | ||||
REF 10 | KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance. Oncogene. 2007 Sep 27;26(44):6386-95. | ||||
REF 11 | Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyros... Biochem Biophys Res Commun. 2000 Apr 2;270(1):28-33. |
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