Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56108 | Target Info | |||
| Target Name | Tripartite motif-containing 24 (TRIM24) | ||||
| Synonyms | Tripartite motif-containing protein 24; Transcription intermediary factor 1-alpha; TIF1A; TIF1-alpha; TIF1; RNF82; RING-type E3 ubiquitin transferase TIF1-alpha; RING finger protein 82; E3 ubiquitin-protein ligase TRIM24 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TRIM24 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Protein Name | E3 ubiquitin-protein ligase TRIM33 (TRIM33) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ECTO; PTC7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Reconstituted Complex | [1] | |||
| Histones | [+] 1 Histones | + | |||
| Interacting Protein Name | Histone H3.1 (H31) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | H3/A; H3FA | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Affinity Capture-Western | [4] | |||
| 3 | Co-crystal Structure | [5] | |||
| 4 | Protein-peptide | [5] | |||
| Nuclear hormone receptors | [+] 4 Nuclear hormone receptors | + | |||
| Interacting Target Name | Estrogen receptor (ESR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Reconstituted Complex | [7] | |||
| Interacting Target Name | Androgen receptor (AR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [8] | |||
| 2 | Reconstituted Complex | [9] | |||
| Interacting Target Name | Estrogen receptor beta (ESR2) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Oestrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; NR3A2; ESTRB; ER-beta; Erbeta; Beta-1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [10] | |||
| 2 | Fluorescence Resonance Energy Transfer | [11] | |||
| Interacting Target Name | Peroxisome proliferator-activated receptor gamma (PPAR-gamma) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Fluorescence Resonance Energy Transfer | [11] | |||
| 2 | Protein-peptide | [12] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression. J Mol Biol. 2002 Jul 12;320(3):629-44. | ||||
| REF 2 | TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage. Mol Cell Biol. 2014 Jul;34(14):2695-709. | ||||
| REF 3 | Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding. Cancer Res. 2017 Nov 15;77(22):6190-6201. | ||||
| REF 4 | TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma. Nat Commun. 2017 Nov 13;8(1):1454. | ||||
| REF 5 | TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010 Dec 16;468(7326):927-32. | ||||
| REF 6 | Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain. J Biol Chem. 1998 Oct 23;273(43):28371-7. | ||||
| REF 7 | Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 1996 Jan 2;15(1):110-24. | ||||
| REF 8 | TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. Biochim Biophys Acta. 2009 Dec;1793(12):1828-36. | ||||
| REF 9 | Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J Biol Chem. 1997 May 2;272(18):12062-8. | ||||
| REF 10 | A large set of estrogen receptor -interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Proteomics. 2011 Jan;11(1):159-65. | ||||
| REF 11 | Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres. Cytometry. 2001 Aug 1;44(4):326-37. | ||||
| REF 12 | T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277(22):19649-57. | ||||
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