Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T58470 Target Info
Target Name Cyclin A2 (CCNA2)
Synonyms Cyclin-A2; Cyclin-A; Cyclin A; CCNA
Target Type Literature-reported Target
Gene Name CCNA2
UniProt ID
CCNA2_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 2 Beta-transducin repeats +
Interacting Protein Name Cell division cycle protein 20 homolog (CDC20) Interacting Protein Interacting Protein Info
UniProt ID
CDC20_HUMAN 
Synonyms CDC20A; bA276H19.3; p55CDC
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Protein-peptide [4]
8 Reconstituted Complex [6]
9 Reconstituted Complex [3]
Interacting Protein Name Fizzy-related protein homolog (FZR1) Interacting Protein Interacting Protein Info
UniProt ID
FZR1_HUMAN 
Synonyms CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Reconstituted Complex [6]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-like protein 1 (RBL1) Interacting Protein Interacting Protein Info
UniProt ID
RBL1_HUMAN 
Synonyms CP107; PRB1; p107
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [9]
Histones [+] 1 Histones +
Interacting Protein Name Histone H1.1 (HIST1H1A) Interacting Protein Interacting Protein Info
UniProt ID
H11_HUMAN 
Synonyms H1.1; H1A; H1F1; HIST1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [11]
3 Biochemical Activity [12]
4 Biochemical Activity [13]
5 Biochemical Activity [14]
6 Biochemical Activity [15]
7 Biochemical Activity [16]
Kinases [+] 3 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 17 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [17]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [3]
6 Affinity Capture-Western [5]
7 Affinity Capture-Western [6]
8 Affinity Capture-Western [19]
9 Affinity Capture-Western [20]
10 Affinity Capture-Western [9]
11 Affinity Capture-Western [21]
12 Affinity Capture-Western [22]
13 Affinity Capture-Western [13]
14 Affinity Capture-Western [23]
15 Co-crystal Structure [24]
16 Reconstituted Complex [25]
17 Reconstituted Complex [26]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [17]
5 Affinity Capture-Western [6]
6 Affinity Capture-Western [27]
7 Affinity Capture-Western [12]
8 Affinity Capture-Western [28]
9 Affinity Capture-Western [19]
10 Affinity Capture-Western [20]
Interacting Target Name Cyclin-dependent kinase 7 (CDK7) Clinical trial Target Interacting Protein Info
UniProt ID
CDK7_HUMAN 
Synonyms TFIIH basal transcription factor complex kinase subunit; Serine/threonine-protein kinase 1; P39 Mo15; MO15; Cell division protein kinase 7; CDKN7; CDK-activating kinase 1; CDK-activating kinase; CAK1; CAK; 39 kDa protein kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Biochemical Activity [30]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Reconstituted Complex [32]
3 Reconstituted Complex [31]
Other proteins [+] 6 Other proteins +
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [33]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [27]
6 Affinity Capture-Western [28]
7 Affinity Capture-Western [14]
8 Reconstituted Complex [34]
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [33]
5 Affinity Capture-Western [18]
6 Affinity Capture-Western [21]
7 Affinity Capture-Western [35]
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [35]
5 Affinity Capture-Western [36]
Interacting Target Name CDK inhibitor 1C p57Kip2 (CDKN1C) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1C_HUMAN 
Synonyms P57KIP2; P57(KIP2); KIP2; Cyclin-dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [33]
Interacting Protein Name Cyclin-dependent kinases regulatory subunit 1 (CKS1B) Interacting Protein Interacting Protein Info
UniProt ID
CKS1_HUMAN 
Synonyms CKS1; PNAS.16; PNAS.18; ckshs1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
Interacting Protein Name Cyclin-dependent kinases regulatory subunit 2 (CKS2) Interacting Protein Interacting Protein Info
UniProt ID
CKS2_HUMAN 
Synonyms CKSHS2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [6]
References  Top
REF 1 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 2 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 3 How cyclin A destruction escapes the spindle assembly checkpoint. J Cell Biol. 2010 Aug 23;190(4):501-9.
REF 4 The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators. Dev Cell. 2015 Feb 9;32(3):358-372.
REF 5 Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol Cell. 2008 May 9;30(3):290-302.
REF 6 Degradation of cyclin A is regulated by acetylation. Oncogene. 2009 Jul 23;28(29):2654-66.
REF 7 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 8 B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107. Oncogene. 2002 Nov 14;21(52):7923-32.
REF 9 Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10453-8.
REF 10 A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation. Oncogene. 2012 Aug 30;31(35):3989-98.
REF 11 PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell. 1998 Dec;2(6):877-85.
REF 12 The cyclin box and C-terminus of cyclins A and E specify CDK activation and substrate specificity. Oncogene. 1997 Jan 30;14(4):491-8.
REF 13 Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest. Mol Cell Biol. 2002 May;22(9):2993-3002.
REF 14 Modulation of cell cycle control by vitamin D3 and its analogue, EB1089, in human breast cancer cells. Oncogene. 1997 Sep 25;15(13):1555-63.
REF 15 Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Eur J Biochem. 1996 Apr 15;237(2):460-7.
REF 16 p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function. Cancer Lett. 2009 Dec 28;286(2):240-9.
REF 17 Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Oncogene. 2003 Jul 10;22(28):4301-13.
REF 18 Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell. 1998 Mar;1(4):553-63.
REF 19 G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
REF 20 APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint. J Biol Chem. 2014 Feb 7;289(6):3457-67.
REF 21 Differential modulation of G1-S-phase cyclin-dependent kinase 2/cyclin complexes occurs during the acquisition of a polyploid DNA content. Cell Growth Differ. 1998 Aug;9(8):639-50.
REF 22 Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3521-4.
REF 23 Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. J Biol Chem. 1996 May 31;271(22):13283-91.
REF 24 Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature. 1995 Jul 27;376(6538):313-20.
REF 25 Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell. 2002 Apr;9(4):761-71.
REF 26 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell. 2011 Jan 21;144(2):187-99.
REF 27 APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell. 2007 Aug 3;27(3):462-73.
REF 28 Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells. J Cell Biochem. 2011 Apr;112(4):1176-91.
REF 29 Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol. 2006 Jan;13(1):55-62.
REF 30 Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. Mol Cell Biol. 2001 Jan;21(1):88-99.
REF 31 Modulation of Sp1 activity by a cyclin A/CDK complex. J Mol Biol. 2001 Feb 16;306(2):201-12.
REF 32 Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. EMBO J. 2001 Oct 15;20(20):5737-47.
REF 33 The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain. J Biol Chem. 2003 Nov 7;278(45):44255-64.
REF 34 Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol. 1996 Sep;16(9):4673-82.
REF 35 Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation. Mol Cell Endocrinol. 2017 Jan 5;439:1-9.
REF 36 p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell. 1995 Sep 22;82(6):915-25.

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