Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T58970 Target Info
Target Name Extracellular signal-regulated kinase 2 (ERK2)
Synonyms PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
Target Type Clinical trial Target
Gene Name MAPK1
Biochemical Class Kinase
UniProt ID
MK01_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Regulatory-associated protein of mTOR (RPTOR) Interacting Protein Interacting Protein Info
UniProt ID
RPTOR_HUMAN 
Synonyms KOG1; Mip1
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [1]
2 Biochemical Activity [2]
3 Reconstituted Complex [1]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Dual specificity protein phosphatase 1 (DUSP1) Clinical trial Target Interacting Protein Info
UniProt ID
DUS1_HUMAN 
Synonyms VH1; PTPN10; Protein-tyrosine phosphatase CL100; MKP-1; MKP1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase-1; MAP kinase phosphatase 1; Dual specificity protein phosphatase hVH1; CL100
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Biochemical Activity [5]
4 Yeast two hybrid [4]
Interacting Protein Name Dual specificity protein phosphatase 6 (DUSP6) Interacting Protein Interacting Protein Info
UniProt ID
DUS6_HUMAN 
Synonyms HH19; MKP3; PYST1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [8]
Kinases [+] 10 Kinases +
Interacting Target Name ERK activator kinase 1 (MEK1) Clinical trial Target Interacting Protein Info
UniProt ID
MP2K1_HUMAN 
Synonyms PRKMK1; MKK1; Mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERKkinase 1; MAPK/ERK kinase 1; MAP kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [12]
5 Biochemical Activity [9]
6 Protein-Fragment Complementation Assay [13]
7 Reconstituted Complex [14]
8 Reconstituted Complex [15]
9 Yeast two hybrid [16]
Interacting Target Name Ribosomal protein S6 kinase alpha-1 (RSK1) Patented-recorded Target Interacting Protein Info
UniProt ID
KS6A1_HUMAN 
Synonyms S6K-alpha-1; RSK-1; Ribosomal S6 kinase 1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; MAPKAPK1A; MAPKAP kinase 1a; MAPK-activated protein kinase 1a; MAP kinase-activated protein kinase 1a; 90 kDa ribosomal protein S6 kinase 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [17]
2 Affinity Capture-Western [18]
3 Affinity Capture-Western [12]
4 Biochemical Activity [19]
5 Reconstituted Complex [20]
Interacting Target Name Ribosomal protein S6 kinase alpha-3 (RSK3) Patented-recorded Target Interacting Protein Info
UniProt ID
KS6A3_HUMAN 
Synonyms S6K-alpha-3; RSK-2; RSK2; Ribosomal S6 kinase 2; pp90RSK2; p90RSK3; p90-RSK 3; MAPKAPK-1b; MAPKAPK1B; MAPKAP kinase 1b; MAPK-activated protein kinase 1b; MAP kinase-activated protein kinase 1b; ISPK-1; ISPK1; Insulin-stimulated protein kinase 1; 90 kDa ribosomal protein S6 kinase 3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [22]
3 Co-localization [23]
4 Reconstituted Complex [24]
5 Yeast two hybrid [25]
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [27]
4 Biochemical Activity [28]
Interacting Target Name ERK activator kinase 2 (MEK2) Clinical trial Target Interacting Protein Info
UniProt ID
MP2K2_HUMAN 
Synonyms PRKMK2; MKK2; MEK 2; MAPKK 2; MAPK/ERK kinase 2; MAP kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2; Dual specificity mitogenactivated protein kinase kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [29]
2 Reconstituted Complex [29]
3 Yeast two hybrid [16]
Interacting Target Name MAPK-activated protein kinase 2 (MAPKAPK2) Clinical trial Target Interacting Protein Info
UniProt ID
MAPK2_HUMAN 
Synonyms MK-2; MK2; MAPKAP-K2; MAPKAPK-2; MAPKAP kinase 2; MAPKactivated protein kinase 2; MAP kinase-activated protein kinase 2; MAP kinaseactivated protein kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [31]
3 Protein-Fragment Complementation Assay [13]
Interacting Target Name Extracellular signal-regulated kinase 1 (ERK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK03_HUMAN 
Synonyms PRKM3; P44-MAPK; P44-ERK1; P44 Mitogen-activated protein kinase; Mitogen-activated protein kinase 3; Microtubule-associated protein-2 kinase; Microtubule-associated protein 2 kinase; MAPK 3; MAP kinase isoform p44; MAP kinase 3; Insulin-stimulated MAP2 kinase; ERT2; ERK-1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [10]
3 Co-fractionation [32]
Interacting Target Name Stress-activated protein kinase 2a (p38 alpha) Clinical trial Target Interacting Protein Info
UniProt ID
MK14_HUMAN 
Synonyms SAPK2A; P38 Mitogen-activatedprotein kinase alpha; P38 mitogen activatedprotein kinase; MXI2; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Protein-Fragment Complementation Assay [13]
Interacting Target Name MAPK/ERK kinase kinase 1 (MAP3K1) Clinical trial Target Interacting Protein Info
UniProt ID
M3K1_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 1; Mitogenactivated protein kinase kinase kinase 1; MEKK1; MEKK 1; MEKK; MEK kinase 1; MAPKKK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Biochemical Activity [34]
Interacting Target Name Ribosomal protein S6 kinase alpha-2 (RSK2) Literature-reported Target Interacting Protein Info
UniProt ID
KS6A2_HUMAN 
Synonyms S6K-alpha-2; RSK-3; RSK3; Ribosomal S6 kinase 3; pp90RSK3; p90RSK2; p90-RSK 2; MAPKAPK-1c; MAPKAPK1C; MAPKAP kinase 1c; MAPK-activated protein kinase 1c; MAP kinase-activated protein kinase 1c; 90 kDa ribosomal protein S6 kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [35]
2 Affinity Capture-Western [36]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [37]
2 Affinity Capture-Western [38]
3 Co-localization [23]
4 Protein-Fragment Complementation Assay [13]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name ETS domain-containing protein Elk-1 (ELK1) Interacting Protein Interacting Protein Info
UniProt ID
ELK1_HUMAN 
Evidence Score (E-score) 17 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Affinity Capture-Western [40]
3 Affinity Capture-Western [41]
4 Biochemical Activity [19]
5 Biochemical Activity [42]
6 Biochemical Activity [43]
7 Biochemical Activity [29]
8 Biochemical Activity [44]
9 Biochemical Activity [45]
10 Biochemical Activity [46]
11 Biochemical Activity [47]
12 Biochemical Activity [48]
13 Biochemical Activity [49]
14 Biochemical Activity [50]
15 Biochemical Activity [51]
16 Biochemical Activity [52]
17 Reconstituted Complex [53]
Interacting Target Name Myelin basic protein (MBP) Clinical trial Target Interacting Protein Info
UniProt ID
MBP_HUMAN 
Synonyms Myelin membrane encephalitogenic protein; Myelin A1 protein
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Biochemical Activity [54]
3 Biochemical Activity [55]
4 Biochemical Activity [56]
5 Biochemical Activity [57]
6 Biochemical Activity [8]
7 Biochemical Activity [51]
8 Biochemical Activity [27]
9 Biochemical Activity [58]
10 Biochemical Activity [59]
11 Biochemical Activity [60]
12 Biochemical Activity [61]
13 Biochemical Activity [62]
14 Biochemical Activity [63]
15 Biochemical Activity [64]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [65]
2 Biochemical Activity [66]
3 Reconstituted Complex [66]
Other proteins [+] 3 Other proteins +
Interacting Protein Name TNFAIP3-interacting protein 1 (TNIP1) Interacting Protein Interacting Protein Info
UniProt ID
TNIP1_HUMAN 
Synonyms ABIN.1; NAF1; VAN; nip40.1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [67]
2 Affinity Capture-Western [68]
3 Reconstituted Complex [67]
4 Yeast two hybrid [25]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [69]
2 Affinity Capture-Western [70]
3 Co-localization [23]
Interacting Target Name Tumor necrosis factor receptor type I (TNF-R1) Clinical trial Target Interacting Protein Info
UniProt ID
TNR1A_HUMAN 
Synonyms Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-RI; TNFR-I; TNFR1; TNFAR; TBPI; p60; p55; CD120a
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [71]
2 Biochemical Activity [72]
References  Top
REF 1 ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1). J Biol Chem. 2011 Jan 7;286(1):567-77.
REF 2 The identification of raptor as a substrate for p44/42 MAPK. Endocrinology. 2011 Apr;152(4):1264-73.
REF 3 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 4 Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. J Biol Chem. 2001 May 11;276(19):16491-500.
REF 5 Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science. 1999 Dec 24;286(5449):2514-7.
REF 6 Smooth muscle 22 facilitates angiotensin II-induced signaling and vascular contraction. J Mol Med (Berl). 2015 May;93(5):547-58.
REF 7 BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4. Leukemia. 2015 Nov;29(11):2248-56.
REF 8 Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science. 1998 May 22;280(5367):1262-5.
REF 9 p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels. Mol Cell Biol. 2003 May;23(9):3079-90.
REF 10 Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling. Eur J Cell Biol. 2009 Feb;88(2):103-15.
REF 11 Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation. Nat Cell Biol. 2011 Mar;13(3):282-91.
REF 12 PPAR recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement. J Neurosci. 2014 Mar 12;34(11):4054-63.
REF 13 Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation. Biochem J. 2011 Sep 15;438(3):495-503.
REF 14 Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol. 2000 May;20(9):3079-85.
REF 15 A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J Cell Biol. 2001 Feb 19;152(4):765-76.
REF 16 Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1. J Biol Chem. 2002 Apr 26;277(17):14844-52.
REF 17 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 18 Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell. 2005 Jul 22;19(2):159-70.
REF 19 Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J Biol Chem. 2003 Apr 25;278(17):14926-35.
REF 20 Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J Biol Chem. 1999 Jan 29;274(5):2893-8.
REF 21 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 22 Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. J Biol Chem. 1996 Nov 22;271(47):29773-9.
REF 23 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 24 Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529. J Biol Chem. 2008 Feb 22;283(8):4652-7.
REF 25 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 26 Complexes formation between insulin receptor and extracellular signal-regulated kinases ERKs. Mol Cell Biol Res Commun. 2000 Oct;4(4):234-8.
REF 27 G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals. Mol Cell Biol. 2000 Sep;20(18):6837-48.
REF 28 Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell. 2005 Jan 21;17(2):215-24.
REF 29 A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem. 2003 Aug 29;278(35):32662-72.
REF 30 P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity. FEBS Lett. 2004 Apr 23;564(1-2):205-11.
REF 31 Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol. 2003 Aug;23(15):5376-87.
REF 32 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 33 MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem. 2000 Dec 22;275(51):40120-7.
REF 34 RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. J Biol Chem. 2004 Jan 16;279(3):1872-7.
REF 35 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 36 Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol. 2003 Jul;23(14):4796-804.
REF 37 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531.
REF 38 Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway. J Biol Chem. 2011 Mar 11;286(10):8565-76.
REF 39 Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. PLoS Genet. 2011 Jun;7(6):e1002112.
REF 40 p44/42 MAP kinase-dependent regulation of catalase by autocrine human growth hormone protects human mammary carcinoma cells from oxidative stress-induced apoptosis. Oncogene. 2005 May 26;24(23):3774-85.
REF 41 Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9188-93.
REF 42 Contribution of the membrane-distal tyrosine in intracellular signaling by the granulocyte colony-stimulating factor receptor. J Biol Chem. 2004 Jan 2;279(1):326-40.
REF 43 Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction. J Cell Sci. 1995 Nov;108 ( Pt 11):3599-609.
REF 44 Specificity determinants of substrate recognition by the protein kinase DYRK1A. J Biol Chem. 2000 Jan 28;275(4):2431-8.
REF 45 A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010 Jun;24(6):1151-64.
REF 46 CD40-mediated tumor necrosis factor receptor-associated factor 3 signaling upregulates IL-4-induced germline Cepsilon transcription in a human B cell line. Arch Biochem Biophys. 2002 Sep 15;405(2):199-204.
REF 47 Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem. 2003 Apr 11;278(15):13061-8.
REF 48 Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression. J Biol Chem. 2005 Mar 25;280(12):11961-72.
REF 49 Direct integrin alphavbeta6-ERK binding: implications for tumour growth. Oncogene. 2002 Feb 21;21(9):1370-80.
REF 50 Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. EMBO J. 1997 Apr 1;16(7):1620-7.
REF 51 Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J. 1995 Dec 1;14(23):5957-64.
REF 52 The tyrosine kinase Syk regulates TPL2 activation signals. J Biol Chem. 2006 Jan 20;281(3):1371-80.
REF 53 alpha-Synuclein forms a complex with transcription factor Elk-1. J Neurochem. 2001 Apr;77(1):239-52.
REF 54 The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol. 2007 Nov;9(11):1243-52.
REF 55 The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6041-6.
REF 56 Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem. 1999 Sep 3;274(36):25726-34.
REF 57 MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. J Biol Chem. 2003 Apr 18;278(16):14013-9.
REF 58 Dual phosphorylation of phosphoinositide 3-kinase adaptor Grb2-associated binder 2 is responsible for superoxide formation synergistically stimulated by Fc gamma and formyl-methionyl-leucyl-phenylalanine receptors in differentiated THP-1 cells. J Immunol. 2003 Oct 15;171(8):4227-34.
REF 59 Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast. Exp Cell Res. 2001 Oct 1;269(2):287-300.
REF 60 Activation of mitogen-activated protein kinase by the bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation-triggered internalization. FEBS Lett. 1999 May 28;451(3):337-41.
REF 61 Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway. Biol Chem. 2001 Jan;382(1):135-9.
REF 62 A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24;287(35):29273-84.
REF 63 The p38 pathway provides negative feedback for Ras proliferative signaling. J Biol Chem. 2000 Dec 15;275(50):38973-80.
REF 64 EGFRvIII-mediated radioresistance through a strong cytoprotective response. Oncogene. 2003 Aug 28;22(36):5545-53.
REF 65 Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase. Structure. 2018 Jan 2;26(1):28-39.e2.
REF 66 Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm. J Biol Chem. 1999 Jul 30;274(31):21900-7.
REF 67 A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling. Biochem Biophys Res Commun. 2002 Sep 13;297(1):17-23.
REF 68 Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis. PLoS One. 2015 Jun 5;10(6):e0127957.
REF 69 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6.
REF 70 Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J Biol Chem. 2005 Apr 15;280(15):15315-24.
REF 71 Inflammatory protein sPLA(2)-IIA abrogates TNFalpha-induced apoptosis in human astroglioma cells: Crucial role of ERK. Biochim Biophys Acta. 2009 Dec;1793(12):1837-47.
REF 72 Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2). Biochem Biophys Res Commun. 2001 Oct 26;288(2):313-20.

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