Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59875 | Target Info | |||
| Target Name | Estrogen-related receptor-gamma (ESRRG) | ||||
| Synonyms | Nuclear receptor subfamily 3 group B member 3; NR3B3; KIAA0832; Estrogen-related receptor gamma; Estrogen receptor-related protein 3; ERRG2; ERR3; ERR gamma-2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ESRRG | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Protein Name | Nuclear receptor coactivator 1 (NCOA1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [1] | |||
| 2 | Yeast two hybrid | [2] | |||
| Nuclear hormone receptors | [+] 2 Nuclear hormone receptors | + | |||
| Interacting Target Name | Estrogen-related receptor-alpha (ESRRA) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Nuclear receptor subfamily 3 group B member 1; NR3B1; Estrogen-relatedreceptor, alpha; Estrogen-relatedreceptor alpha; Estrogen-related receptor alpha; Estrogen receptor-like 1; ESRL1; ERR-alpha; ERRalpha; ERR1 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Co-localization | [4] | |||
| 3 | Reconstituted Complex | [5] | |||
| 4 | Yeast two hybrid | [2] | |||
| Interacting Target Name | Orphan nuclear receptor SHP (NR0B2) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Reconstituted Complex | [7] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | Nuclear receptor-interacting protein 1 (NRIP1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | RIP140 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [8] | |||
| 2 | Yeast two hybrid | [2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. Mol Cell. 2002 Feb;9(2):303-13. | ||||
| REF 2 | Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13. | ||||
| REF 3 | Interplay between estrogen-related receptor alpha (ERRalpha) and gamma (ERRgamma) on the regulation of ERRalpha gene expression. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):128-41. | ||||
| REF 4 | PGC-1alpha induces dynamic protein interactions on the ERRalpha gene multi-hormone response element nucleosome in kidney cells. Biochem J. 2008 Dec 15;416(3):407-19. | ||||
| REF 5 | Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab. 2007 May;5(5):345-56. | ||||
| REF 6 | Nuclear receptor SHP inhibition of Dnmt1 expression via ERR. FEBS Lett. 2011 May 6;585(9):1269-75. | ||||
| REF 7 | Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes. J Biol Chem. 2010 Aug 6;285(32):24871-81. | ||||
| REF 8 | Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes. Mol Endocrinol. 2006 May;20(5):1035-47. | ||||
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