Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T60213 Target Info
Target Name Bone morphogenetic protein receptor (BMPR2)
Synonyms PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II; BMPR-II; BMPR-2; BMP type-2 receptor; BMP type II receptor
Target Type Literature-reported Target
Gene Name BMPR2
Biochemical Class Kinase
UniProt ID
BMPR2_HUMAN 
Target Interacting Proteins  Top
Growth factors [+] 2 Growth factors +
Interacting Target Name Bone morphogenetic protein 4 (BMP4) Literature-reported Target Interacting Protein Info
UniProt ID
BMP4_HUMAN 
Synonyms DVR4; Bone morphogenetic protein 2B; BMP-4; BMP-2B; BMP2B
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [3]
Interacting Target Name Bone morphogenetic protein 2 (BMP2) Clinical trial Target Interacting Protein Info
UniProt ID
BMP2_HUMAN 
Synonyms Bone morphogenetic protein 2A; BMP-2A; BMP2A; BMP-2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [5]
Kinases [+] 1 Kinases +
Interacting Target Name Activin receptor-like kinase 2 (ALK-2) Clinical trial Target Interacting Protein Info
UniProt ID
ACVR1_HUMAN 
Synonyms TSR-I; TGF-B superfamily receptor type I; SKR1; Serine/threonine-protein kinase receptor R1; ACVRLK2; ACTR-I; Activin receptor type-1; Activin receptor type I
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [4]
3 Yeast two hybrid [4]
4 Yeast two hybrid [7]
References  Top
REF 1 Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7632-6.
REF 2 Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension. Hum Mol Genet. 2002 Jun 15;11(13):1517-25.
REF 3 Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic. J Biol Chem. 2017 Mar 10;292(10):4138-4151.
REF 4 Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol. 1995 Jul;15(7):3479-86.
REF 5 BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. EMBO J. 2000 Jul 3;19(13):3314-24.
REF 6 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 7 Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor. J Biol Chem. 1995 Mar 10;270(10):5625-30.

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