Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T68163 Target Info
Target Name Tyrosine-protein kinase Lyn (JTK8)
Synonyms p56Lyn; p53Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Lck/Yes-related novel protein tyrosine kinase
Target Type Clinical trial Target
Gene Name LYN
Biochemical Class Kinase
UniProt ID
LYN_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Reconstituted Complex [5]
Cytokine receptors [+] 1 Cytokine receptors +
Interacting Target Name Interleukin 3 receptor (CSF2RB) Clinical trial Target Interacting Protein Info
UniProt ID
IL3RB_HUMAN 
Synonyms IL5RB; IL-5R; IL3RB; GM-CSF/IL-3/IL-5 receptor common beta subunit; Cytokine receptor common subunit beta; CDw131; CD131
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Protein-peptide [7]
Kinases [+] 3 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [8]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [9]
4 Protein-Fragment Complementation Assay [8]
5 Yeast two hybrid [10]
Interacting Target Name PI3-kinase gamma (PIK3CG) Successful Target Interacting Protein Info
UniProt ID
PK3CG_HUMAN 
Synonyms Serine/threonine protein kinase PIK3CG; PtdIns-3-kinase subunit p110-gamma; PtdIns-3-kinase subunit gamma; PtdIns-3-kinase p110; PI3-kinase subunit gamma; PI3-kinase p110 subunit gamma; PI3K-gamma; PI3Kgamma; PI3K; Phosphoinositol-3 kinase; Phosphoinositide-3-kinase catalytic gamma polypeptide; Phosphoinositide 3-Kinase gamma; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; p120-PI3K; p110gamma
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [4]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Affinity Capture-Western [13]
3 Biochemical Activity [12]
Other proteins [+] 2 Other proteins +
Interacting Target Name Platelet glycoprotein VI (GP6) Clinical trial Target Interacting Protein Info
UniProt ID
GPVI_HUMAN 
Synonyms GPVI; Glycoprotein 6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [14]
Interacting Target Name GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) Literature-reported Target Interacting Protein Info
UniProt ID
KHDR1_HUMAN 
Synonyms Src-associated in mitosis 68 kDa protein; Srcassociated in mitosis 68 kDa protein; Sam68; p68; p21 Ras GTPase-activating protein-associated p62; p21 Ras GTPaseactivating proteinassociated p62; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; GAPassociated tyrosine phosphoprotein p62
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Biochemical Activity [2]
References  Top
REF 1 c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. J Immunol. 2002 Oct 1;169(7):3793-800.
REF 2 Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem. 2004 Aug 27;279(35):36259-67.
REF 3 Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. Blood. 2008 Apr 1;111(7):3821-9.
REF 4 Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors. J Biol Chem. 1995 Apr 21;270(16):9115-20.
REF 5 Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. J Biol Chem. 1995 Jun 16;270(24):14347-51.
REF 6 Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e). J Immunol. 1995 Aug 15;155(4):2165-74.
REF 7 The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J Immunol. 1999 Feb 1;162(3):1496-501.
REF 8 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 9 Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation ... Mol Cell Proteomics. 2006 Sep;5(9):1610-27.
REF 10 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 11 Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets. J Biol Chem. 1999 May 14;274(20):14368-75.
REF 12 Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation. J Biol Chem. 1994 Aug 12;269(32):20739-43.
REF 13 The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2. J Biol Chem. 1996 Nov 1;271(44):27517-23.
REF 14 Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem. 2002 Jun 14;277(24):21561-6.
REF 15 Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. PLoS One. 2012;7(6):e38540.

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