Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T72319 Target Info
Target Name Chromobox protein homolog 7 (CBX7)
Synonyms Chromobox 7
Target Type Literature-reported Target
Gene Name CBX7
UniProt ID
CBX7_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RING1 (RING1) Interacting Protein Interacting Protein Info
UniProt ID
RING1_HUMAN 
Synonyms RING1A; RNF1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [3]
6 Reconstituted Complex [4]
7 Reconstituted Complex [3]
Interacting Protein Name E3 ubiquitin-protein ligase RING2 (RNF2) Interacting Protein Interacting Protein Info
UniProt ID
RING2_HUMAN 
Synonyms BAP.1; BAP1; DING; HIPI3; RING1B; RING2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [2]
5 Affinity Capture-MS [3]
6 Affinity Capture-Western [3]
7 Reconstituted Complex [3]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [7]
3 Biochemical Activity [7]
4 Co-localization [8]
5 Reconstituted Complex [7]
Kinases [+] 1 Kinases +
Interacting Protein Name Casein kinase II subunit beta (CSNK2B) Interacting Protein Interacting Protein Info
UniProt ID
CSK2B_HUMAN 
Synonyms CK2B; CK2N; CSK2B; G5A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [6]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Polycomb group RING finger protein 6 (PCGF6) Interacting Protein Interacting Protein Info
UniProt ID
PCGF6_HUMAN 
Synonyms MBLR; RNF134
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [2]
5 Affinity Capture-MS [3]
6 Reconstituted Complex [3]
Interacting Protein Name Polycomb group RING finger protein 2 (PCGF2) Interacting Protein Interacting Protein Info
UniProt ID
PCGF2_HUMAN 
Synonyms MEL.18; RNF110; ZNF144
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Reconstituted Complex [3]
Other proteins [+] 4 Other proteins +
Interacting Target Name Polycomb complex protein BMI-1 (BMI1) Clinical trial Target Interacting Protein Info
UniProt ID
BMI1_HUMAN 
Synonyms RNF51; RING finger protein 51; Polycomb group RING finger protein 4; PCGF4
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [2]
5 Affinity Capture-MS [3]
6 Affinity Capture-Western [1]
7 Affinity Capture-Western [3]
8 Reconstituted Complex [3]
Interacting Protein Name Polyhomeotic-like protein 2 (PHC2) Interacting Protein Interacting Protein Info
UniProt ID
PHC2_HUMAN 
Synonyms EDR2; HPH2; PH2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [2]
5 Affinity Capture-MS [3]
Interacting Protein Name Polycomb group RING finger protein 3 (PCGF3) Interacting Protein Interacting Protein Info
UniProt ID
PCGF3_HUMAN 
Synonyms DONG1; RNF3; RNF3A
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [3]
Interacting Protein Name Polycomb group RING finger protein 1 (PCGF1) Interacting Protein Interacting Protein Info
UniProt ID
PCGF1_HUMAN 
Synonyms 2010002K04Rik; NSPC1; RNF3A.2; RNF68
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Reconstituted Complex [3]
References  Top
REF 1 Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS One. 2009 Jul 28;4(7):e6380.
REF 2 A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595.
REF 3 Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics. 2011 Apr;10(4):M110.002642.
REF 4 Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol. 2004 Jan;6(1):67-72.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 7 Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Cancer Res. 2009 Sep 1;69(17):7079-87.
REF 8 CBX7 is a tumor suppressor in mice and humans. J Clin Invest. 2012 Feb;122(2):612-23.

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