Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T77393 Target Info
Target Name WD repeat-containing protein 5 (WDR5)
Synonyms BMP2-induced 3-kb gene protein; BIG3
Target Type Literature-reported Target
Gene Name WDR5
UniProt ID
WDR5_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Interacting Protein Info
UniProt ID
KAT2B_HUMAN 
Synonyms Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Interacting Protein Name Histone acetyltransferase KAT2A (KAT2A) Interacting Protein Interacting Protein Info
UniProt ID
KAT2A_HUMAN 
Synonyms GCN5; GCN5L2; PCAF.b; hGCN5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [5]
Histones [+] 2 Histones +
Interacting Protein Name Histone H3.1 (H31) Interacting Protein Interacting Protein Info
UniProt ID
H31_HUMAN 
Synonyms H3/A; H3FA
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Co-crystal Structure [8]
4 Co-crystal Structure [9]
5 Co-crystal Structure [10]
6 Co-crystal Structure [11]
7 Reconstituted Complex [6]
Interacting Protein Name Histone H3.1t (HIST3H3) Interacting Protein Interacting Protein Info
UniProt ID
H31T_HUMAN 
Synonyms H3.4; H3/g; H3FT; H3t
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Biochemical Activity [13]
3 Co-crystal Structure [14]
4 Reconstituted Complex [15]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [16]
One-carbon transferases [+] 6 One-carbon transferases +
Interacting Target Name Mixed-lineage leukemia protein (MLL) Literature-reported Target Interacting Protein Info
UniProt ID
KMT2A_HUMAN 
Synonyms Zinc finger protein HRX; Trithorax-like protein; Trithoraxlike protein; p320; p180; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Myeloid/lymphoid or mixed-lineage leukemia; MLL1; MLL cleavage product C180; Lysine N-methyltransferase 2A; Lysine Nmethyltransferase 2A; HTRX; HRX; Histonelysine Nmethyltransferase MLL; Histone-lysine N-methyltransferase 2A; CXXC-type zinc finger protein 7; CXXCtype zinc finger protein 7; CXXC7; ALL-1; ALL1
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-MS [17]
5 Affinity Capture-Western [18]
6 Co-crystal Structure [19]
7 Co-purification [18]
8 Protein-peptide [20]
9 Protein-peptide [21]
10 Reconstituted Complex [22]
Interacting Protein Name Histone-lysine N-methyltransferase 2D (KMT2D) Interacting Protein Interacting Protein Info
UniProt ID
KMT2D_HUMAN 
Synonyms AAD10; ALR; CAGL114; KABUK1; KMS; MLL2; MLL4; TNRC21
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [5]
6 Co-crystal Structure [20]
7 Protein-peptide [20]
8 Reconstituted Complex [15]
Interacting Protein Name Histone-lysine N-methyltransferase SETD1A (SETD1A) Interacting Protein Interacting Protein Info
UniProt ID
SET1A_HUMAN 
Synonyms KMT2F; Set1; Set1A
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-MS [17]
5 Affinity Capture-Western [23]
6 Affinity Capture-Western [24]
7 Co-crystal Structure [20]
8 Protein-peptide [20]
Interacting Protein Name Histone-lysine N-methyltransferase 2B (KMT2B) Interacting Protein Interacting Protein Info
UniProt ID
KMT2B_HUMAN 
Synonyms HRX2; MLL1B; MLL2; MLL4; TRX2; WBP.7; WBP7
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-MS [17]
5 Co-crystal Structure [20]
6 Protein-peptide [20]
Interacting Protein Name Histone-lysine N-methyltransferase SETD1B (SETD1B) Interacting Protein Interacting Protein Info
UniProt ID
SET1B_HUMAN 
Synonyms KMT2G; Set1B
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [24]
5 Co-crystal Structure [20]
6 Protein-peptide [20]
Interacting Protein Name Histone-lysine N-methyltransferase 2C (KMT2C) Interacting Protein Interacting Protein Info
UniProt ID
KMT2C_HUMAN 
Synonyms HALR; MLL3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-crystal Structure [20]
3 Protein-peptide [20]
Transcription regulators [+] 4 Transcription regulators +
Interacting Protein Name CXXC-type zinc finger protein 1 (CXXC1) Interacting Protein Interacting Protein Info
UniProt ID
CXXC1_HUMAN 
Synonyms 2410002I16Rik; 5830420C16Rik; CFP1; CGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1; hCGBP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-MS [17]
5 Affinity Capture-Western [23]
Interacting Protein Name Transcriptional adapter 3 (TADA3) Interacting Protein Interacting Protein Info
UniProt ID
TADA3_HUMAN 
Synonyms ADA3; NGG1; STAF54; TADA3L; hADA3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [3]
Interacting Protein Name Zinc finger protein ZXDC (ZXDC) Interacting Protein Interacting Protein Info
UniProt ID
ZXDC_HUMAN 
Synonyms ZXDL
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Yeast two hybrid [25]
Interacting Protein Name Protein Dr1 (DR1) Interacting Protein Interacting Protein Info
UniProt ID
NC2B_HUMAN 
Synonyms NC2; NC2.BETA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Other proteins [+] 13 Other proteins +
Interacting Protein Name Retinoblastoma-binding protein 5 (RBBP5) Interacting Protein Interacting Protein Info
UniProt ID
RBBP5_HUMAN 
Synonyms RBQ3; SWD1
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-MS [17]
5 Affinity Capture-Western [23]
6 Affinity Capture-Western [26]
7 Affinity Capture-Western [6]
8 Affinity Capture-Western [27]
9 Affinity Capture-Western [7]
10 Affinity Capture-Western [28]
11 Affinity Capture-Western [29]
12 Co-crystal Structure [19]
13 Protein-peptide [19]
Interacting Protein Name Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) Interacting Protein Interacting Protein Info
UniProt ID
ASH2L_HUMAN 
Synonyms ASH2; ASH2L1; ASH2L2; Bre2
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [4]
5 Affinity Capture-MS [17]
6 Affinity Capture-Western [23]
7 Affinity Capture-Western [26]
8 Affinity Capture-Western [6]
9 Affinity Capture-Western [30]
10 Affinity Capture-Western [27]
11 Affinity Capture-Western [7]
Interacting Protein Name KAT8 regulatory NSL complex subunit 1 (KANSL1) Interacting Protein Interacting Protein Info
UniProt ID
KANL1_HUMAN 
Synonyms CENP.36; KDVS; KIAA1267; MSL1v1; NSL1; hMSL1v1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [15]
5 Co-crystal Structure [15]
6 Reconstituted Complex [15]
Interacting Protein Name MAP3K12-binding inhibitory protein 1 (MBIP) Interacting Protein Interacting Protein Info
UniProt ID
MBIP1_HUMAN 
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [3]
5 Yeast two hybrid [31]
6 Yeast two hybrid [25]
Interacting Protein Name Cysteine-rich protein 2-binding protein (KAT14) Interacting Protein Interacting Protein Info
UniProt ID
CSR2B_HUMAN 
Synonyms ATAC2; CRP2BP; KAT14; PRO1194; dJ717M23.1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [4]
Interacting Protein Name PAX-interacting protein 1 (PAXIP1) Interacting Protein Interacting Protein Info
UniProt ID
PAXI1_HUMAN 
Synonyms CAGF29; PACIP1; PAXIP1L; PTIP; TNRC2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [28]
Interacting Protein Name Transcriptional adapter 2-alpha (TADA2A) Interacting Protein Interacting Protein Info
UniProt ID
TAD2A_HUMAN 
Synonyms ADA2; ADA2A; TADA2L; hADA2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [3]
Interacting Protein Name YEATS domain-containing protein 2 (YEATS2) Interacting Protein Interacting Protein Info
UniProt ID
YETS2_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [3]
Interacting Protein Name Protein dpy-30 homolog (DPY30) Interacting Protein Interacting Protein Info
UniProt ID
DPY30_HUMAN 
Synonyms Cps25; HDPY.30; Saf19
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [17]
3 Affinity Capture-Western [7]
Interacting Protein Name KAT8 regulatory NSL complex subunit 2 (KANSL2) Interacting Protein Interacting Protein Info
UniProt ID
KANL2_HUMAN 
Synonyms C12orf41; NSL2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [15]
3 Reconstituted Complex [15]
Interacting Protein Name YEATS domain-containing protein 1 (MLLT1) Interacting Protein Interacting Protein Info
UniProt ID
ENL_HUMAN 
Synonyms ENL; LTG19; YEATS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [32]
2 Reconstituted Complex [33]
Interacting Protein Name Host cell factor 1 (HCFC1) Interacting Protein Interacting Protein Info
UniProt ID
HCFC1_HUMAN 
Synonyms CFF; HCF; HCF.1; HCF1; HFC1; MRX3; PPP1R89; VCAF
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [17]
Interacting Protein Name SAGA-associated factor 29 (SGF29) Interacting Protein Interacting Protein Info
UniProt ID
SGF29_HUMAN 
Synonyms SGF29; STAF36
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [3]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem. 2008 Dec 5;283(49):33808-15.
REF 4 A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595.
REF 5 The role of WDR5 in silencing human fetal globin gene expression. Haematologica. 2012 Nov;97(11):1632-40.
REF 6 WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell. 2005 Jun 17;121(6):859-72.
REF 7 WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission. J Biol Chem. 2015 Apr 3;290(14):8987-9001.
REF 8 Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO J. 2006 Sep 20;25(18):4245-52.
REF 9 Molecular recognition of histone H3 by the WD40 protein WDR5. Nat Struct Mol Biol. 2006 Aug;13(8):698-703.
REF 10 Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol. 2006 Aug;13(8):704-12.
REF 11 Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Mol Cell. 2006 Apr 7;22(1):137-44.
REF 12 A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. Mol Cell. 2014 May 22;54(4):613-25.
REF 13 An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. PLoS One. 2010 Nov 23;5(11):e14102.
REF 14 Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic. FASEB J. 2011 Mar;25(3):960-7.
REF 15 Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex. Genes Dev. 2014 May 1;28(9):929-42.
REF 16 Identification of the MLL2 complex as a coactivator for estrogen receptor alpha. J Biol Chem. 2006 Jun 9;281(23):15714-20.
REF 17 A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics. 2010 May;9(5):811-23.
REF 18 Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol. 2004 Jul;24(13):5639-49.
REF 19 Structural and biochemical insights into MLL1 core complex assembly. Structure. 2011 Jan 12;19(1):101-8.
REF 20 The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res. 2012 May;40(9):4237-46.
REF 21 Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J. 2013 Jan 1;449(1):151-9.
REF 22 WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. J Biol Chem. 2008 Dec 12;283(50):35258-64.
REF 23 CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. J Biol Chem. 2005 Dec 16;280(50):41725-31.
REF 24 Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. J Biol Chem. 2007 May 4;282(18):13419-28.
REF 25 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 26 WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. J Biol Chem. 2011 Jun 17;286(24):21853-64.
REF 27 Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition. Mol Cell. 2011 Sep 2;43(5):811-22.
REF 28 PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem. 2007 Jul 13;282(28):20395-406.
REF 29 Inivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Rep. 2016 Jun 28;16(1):133-147.
REF 30 Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex. Nat Cell Biol. 2008 Jan;10(1):77-84.
REF 31 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 32 Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. J Biol Chem. 2008 Nov 21;283(47):32158-61.
REF 33 A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex. J Biol Chem. 2008 Nov 21;283(47):32162-75.

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