Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T77594 Target Info
Target Name Endoplasmic reticulum chaperone BiP (HSPA5)
Synonyms Immunoglobulin heavy chainbinding protein; Immunoglobulin heavy chain-binding protein; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; HSP70 family protein 5; GRP78; GRP-78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; Binding-immunoglobulin protein; BiP; 78 kDa glucose-regulated protein
Target Type Clinical trial Target
Gene Name HSPA5
Biochemical Class Acid anhydride hydrolase
UniProt ID
BIP_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Adapter proteins [+] 2 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [3]
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [4]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 6 (HDAC6) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC6_HUMAN 
Synonyms KIAA0901; JM21; HD6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
Heat shock proteins [+] 3 Heat shock proteins +
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Co-fractionation [8]
3 Co-fractionation [9]
Interacting Target Name Endoplasmin (HSP90B1) Clinical trial Target Interacting Protein Info
UniProt ID
ENPL_HUMAN 
Synonyms Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP-94; GRP94; gp96 homolog; 94 kDa glucose-regulated protein; 94 kDa glucoseregulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Co-fractionation [8]
Interacting Protein Name Heat shock 70 kDa protein 1A (HSPA1A) Interacting Protein Interacting Protein Info
UniProt ID
HS71A_HUMAN 
Synonyms HEL.S.103; HSP70.1; HSP70.1A; HSP70I; HSP72; HSPA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Co-fractionation [9]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Protein Name Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) Interacting Protein Interacting Protein Info
UniProt ID
S61A1_HUMAN 
Synonyms HSEC61; SEC61; SEC61A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Protein-peptide [11]
Isomerases [+] 1 Isomerases +
Interacting Protein Name Protein disulfide-isomerase A6 (PDIA6) Interacting Protein Interacting Protein Info
UniProt ID
PDIA6_HUMAN 
Synonyms ERP5; P5; TXNDC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Co-fractionation [9]
Kinases [+] 3 Kinases +
Interacting Target Name Endoplasmic reticulum to nucleus signaling 1 (ERN1) Clinical trial Target Interacting Protein Info
UniProt ID
ERN1_HUMAN 
Synonyms Serine/threonine-protein kinase/endoribonuclease IRE1; Ire1-alpha; IRE1a; IRE1; Inositol-requiring protein 1; hIRE1p; Endoplasmic reticulum-to-nucleus signaling 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Reconstituted Complex [14]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [15]
Interacting Target Name Serine/threonine-protein kinase B-raf (BRAF) Successful Target Interacting Protein Info
UniProt ID
BRAF_HUMAN 
Synonyms V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [16]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Protein Name DnaJ homolog subfamily C member 10 (DNAJC10) Interacting Protein Interacting Protein Info
UniProt ID
DJC10_HUMAN 
Synonyms ERdj5; JPDI; MTHr; PDIA19
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [17]
3 Reconstituted Complex [18]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-Western [20]
Other proteins [+] 7 Other proteins +
Interacting Target Name Epithelial cadherin (CDH1) Literature-reported Target Interacting Protein Info
UniProt ID
CADH1_HUMAN 
Synonyms Uvomorulin; UVO; E-cadherin gene; E-cadherin; CDHE; CD324; CAM 120/80; Cadherin-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Proximity Label-MS [22]
Interacting Target Name Clusterin (CLU) Literature-reported Target Interacting Protein Info
UniProt ID
CLUS_HUMAN 
Synonyms TRPM-2; Testosterone-repressed prostate message 2; Testosteronerepressed prostate message 2; NA1/NA2; KUB1; Ku70-binding protein 1; Ku70binding protein 1; Complement-associated protein SP-40,40; Complementassociated protein SP40,40; Complement cytolysis inhibitor; Clusterin alpha chain; Clusterin; CLI; Apolipoprotein J; Apo-J; ApoJ; Aging-associated gene 4 protein; Agingassociated gene 4 protein; AAG4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-Western [24]
Interacting Target Name Microtubule-associated protein 4 (MAP4) Literature-reported Target Interacting Protein Info
UniProt ID
MAP4_HUMAN 
Synonyms Microtubuleassociated protein 4; MAP4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Co-fractionation [8]
Interacting Protein Name DnaJ homolog subfamily B member 11 (DNAJB11) Interacting Protein Interacting Protein Info
UniProt ID
DJB11_HUMAN 
Synonyms ABBP.2; ABBP2; DJ9; Dj.9; EDJ; ERdj3; ERj3; ERj3p; PRO1080; UNQ537
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Co-fractionation [8]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein U (HNRNPU) Interacting Protein Interacting Protein Info
UniProt ID
HNRPU_HUMAN 
Synonyms HNRPU; SAF.A; U21.1; hnRNP U
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Co-fractionation [8]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) Interacting Protein Interacting Protein Info
UniProt ID
ROA3_HUMAN 
Synonyms 2610510D13Rik; D10S102; FBRNP; HNRPA3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Co-fractionation [9]
Interacting Protein Name Stress-induced-phosphoprotein 1 (STIP1) Interacting Protein Interacting Protein Info
UniProt ID
STIP1_HUMAN 
Synonyms HEL.S.94n; HOP; IEF.SSP.3521; P60; STI1; STI1L
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Co-fractionation [8]
References  Top
REF 1 Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9.
REF 2 PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5. Autophagy. 2018;14(11):1870-1885.
REF 3 Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding. Nat Cell Biol. 2015 Jul;17(7):917-29.
REF 4 A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
REF 5 A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. Cell Death Differ. 2013 Oct;20(10):1306-16.
REF 6 Treatment with panobinostat induces glucose-regulated protein 78 acetylation and endoplasmic reticulum stress in breast cancer cells. Mol Cancer Ther. 2010 Apr;9(4):942-52.
REF 7 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 8 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 9 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 10 Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum. J Biol Chem. 2015 Jul 24;290(30):18621-35.
REF 11 BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER. EMBO J. 2012 Aug 1;31(15):3282-96.
REF 12 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Mol Syst Biol. 2013 Nov 5;9:705.
REF 13 Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways. Cancer Res. 2010 Dec 1;70(23):9949-58.
REF 14 Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. J Biol Chem. 2003 May 16;278(20):17680-7.
REF 15 Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem. 2003 Feb 14;278(7):5292-9.
REF 16 A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Dec;7(23):4228-34.
REF 17 ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol Biol Cell. 2008 Jun;19(6):2620-30.
REF 18 ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. J Biol Chem. 2003 Jan 10;278(2):1059-66.
REF 19 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531.
REF 20 Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis. FEBS Lett. 2007 Jan 9;581(1):131-9.
REF 21 Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes. J Proteome Res. 2005 Sep-Oct;4(5):1646-56.
REF 22 E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal. 2014 Dec 2;7(354):rs7.
REF 23 GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene. 2013 Apr 11;32(15):1933-42.
REF 24 Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PLoS One. 2013;8(2):e55981.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.