Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T78150 Target Info
Target Name Direct IAP-binding protein with low pI (DIABLO)
Synonyms Smac protein; Smac; Second mitochondria-derived activator of caspase; Direct IAP binding protein with low pI; Diablo homolog, mitochondrial
Target Type Literature-reported Target
Gene Name DIABLO
UniProt ID
DBLOH_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 5 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 16 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
8 Affinity Capture-Western [8]
9 Affinity Capture-Western [9]
10 Affinity Capture-Western [10]
11 Biochemical Activity [11]
12 Co-crystal Structure [12]
13 Far Western [4]
14 Protein-peptide [13]
15 Reconstituted Complex [12]
16 Reconstituted Complex [14]
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [15]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [7]
6 Affinity Capture-Western [9]
7 Biochemical Activity [16]
8 Co-crystal Structure [13]
9 Protein-peptide [13]
10 Reconstituted Complex [17]
Interacting Target Name Melanoma inhibitor of apoptosis protein (ML-IAP) Patented-recorded Target Interacting Protein Info
UniProt ID
BIRC7_HUMAN 
Synonyms UNQ5800/PRO19607/PRO21344; RNF50; RING-type E3 ubiquitin transferase BIRC7; RING finger protein 50; MLIAP; Livin; Kidney inhibitor of apoptosis protein; KIAP; Baculoviral IAP repeat-containing protein 7
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [18]
3 Biochemical Activity [19]
4 Co-crystal Structure [20]
Interacting Protein Name Baculoviral IAP repeat-containing protein 6 (BIRC6) Interacting Protein Interacting Protein Info
UniProt ID
BIRC6_HUMAN 
Synonyms APOLLON; BRUCE
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [11]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [7]
Interacting Target Name Cellular inhibitor of apoptosis 2 (BIRC3) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC3_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 1; TNFR2TRAFsignaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; hIAP-1; hIAP1; C-IAP2; CIAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Biochemical Activity [16]
3 Reconstituted Complex [17]
Other proteins [+] 1 Other proteins +
Interacting Target Name Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC5_HUMAN 
Synonyms Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; API4
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [22]
3 Affinity Capture-Western [10]
4 Fluorescence Resonance Energy Transfer [23]
5 Reconstituted Complex [2]
6 Reconstituted Complex [24]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. J Biol Chem. 2003 Jun 20;278(25):23130-40.
REF 3 The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. J Biol Chem. 2005 Jan 7;280(1):174-82.
REF 4 Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein. J Biol Chem. 2003 Dec 26;278(52):52660-72.
REF 5 A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 2001 Mar 1;410(6824):112-6.
REF 6 Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000 Jul 7;102(1):43-53.
REF 7 Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation. PLoS One. 2010 Oct 1;5(10). pii: e13094.
REF 8 Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ. J Biol Chem. 2002 Nov 15;277(46):44236-43.
REF 9 Knockdown of miR-182 promotes apoptosis via regulating RIP1 deubiquitination in TNF--treated triple-negative breast cancer cells. Tumour Biol. 2016 Oct;37(10):13733-13742.
REF 10 Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis. Exp Cell Res. 2005 Jan 1;302(1):69-82.
REF 11 Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol. 2004 Sep;6(9):849-60.
REF 12 Structural basis of IAP recognition by Smac/DIABLO. Nature. 2000 Dec 21-28;408(6815):1008-12.
REF 13 The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):58-66.
REF 14 Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac. J Biol Chem. 2003 Dec 5;278(49):49517-22.
REF 15 Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. J Biol Chem. 2006 Jan 13;281(2):1080-90.
REF 16 The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation. J Biol Chem. 2014 Sep 12;289(37):25721-36.
REF 17 Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. J Biol Chem. 2004 Apr 23;279(17):16963-70.
REF 18 Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma. Int J Oncol. 2015 Nov;47(5):1775-82.
REF 19 Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. Cell Death Differ. 2006 Dec;13(12):2079-88.
REF 20 Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell. 2003 Feb;11(2):519-27.
REF 21 Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem. 2003 Mar 21;278(12):10055-60.
REF 22 A single amino acid change (Asp 53 --> Ala53) converts Survivin from anti-apoptotic to pro-apoptotic. Mol Biol Cell. 2004 Mar;15(3):1287-96.
REF 23 Survivin monomer plays an essential role in apoptosis regulation. J Biol Chem. 2011 Jul 1;286(26):23296-307.
REF 24 Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin Cancer Res. 2013 Feb 1;19(3):631-42.

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