Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T79031 Target Info
Target Name Beta-secretase 1 (BACE1)
Synonyms Membrane-associated aspartic protease 2; Memapsin-2; KIAA1149; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; BACE; Aspartyl protease 2; Asp 2; ASP2
Target Type Clinical trial Target
Gene Name BACE1
Biochemical Class Peptidase
UniProt ID
BACE1_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 3 Other proteins +
Interacting Protein Name ADP-ribosylation factor-binding protein GGA1 (GGA1) Interacting Protein Interacting Protein Info
UniProt ID
GGA1_HUMAN 
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Co-crystal Structure [1]
5 Fluorescence Resonance Energy Transfer [4]
6 Reconstituted Complex [1]
7 Reconstituted Complex [2]
8 Reconstituted Complex [3]
Interacting Protein Name ADP-ribosylation factor-binding protein GGA2 (GGA2) Interacting Protein Interacting Protein Info
UniProt ID
GGA2_HUMAN 
Synonyms VEAR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [3]
3 Reconstituted Complex [1]
Interacting Protein Name ADP-ribosylation factor-binding protein GGA3 (GGA3) Interacting Protein Interacting Protein Info
UniProt ID
GGA3_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [3]
3 Reconstituted Complex [1]
References  Top
REF 1 Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry. 2003 Oct 28;42(42):12174-80.
REF 2 GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Mol Cell Neurosci. 2005 Jul;29(3):453-61.
REF 3 The Golgi-Localized -Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid- Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). PLoS One. 2015 Jun 8;10(6):e0129047.
REF 4 Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy. J Cell Sci. 2004 Oct 15;117(Pt 22):5437-45.

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