Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T80395 | Target Info | |||
Target Name | GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) | ||||
Synonyms | p68; p21 Ras GTPaseactivating proteinassociated p62; p21 Ras GTPase-activating protein-associated p62; Srcassociated in mitosis 68 kDa protein; Src-associated in mitosis 68 kDa protein; Sam68; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; GAPassociated tyrosine phosphoprotein p62 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | KHDRBS1 | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Adapter proteins | [+] 2 Adapter proteins | + | |||
Interacting Protein Name | Growth factor receptor-bound protein 2 (GRB2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2 | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
3 | Protein-peptide | [3] | |||
4 | Reconstituted Complex | [2] | |||
5 | Yeast two hybrid | [4] | |||
Interacting Target Name | NCK adaptor protein 1 (NCK1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | SH2/SH3 adaptor protein NCK-alpha; SH2/SH3 adaptor protein NCKalpha; Nck-1; Nck1; NCK; Cytoplasmic protein NCK1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [5] | |||
2 | Far Western | [5] | |||
3 | Reconstituted Complex | [6] | |||
Ester hydrolases | [+] 1 Ester hydrolases | + | |||
Interacting Protein Name | Phospholipase C-gamma-1 (PLCG1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [2] | |||
2 | Affinity Capture-Western | [7] | |||
3 | Reconstituted Complex | [2] | |||
Kinases | [+] 7 Kinases | + | |||
Interacting Target Name | Proto-oncogene c-Src (SRC) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src | ||||
Evidence Score (E-score) | 7 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [2] | |||
2 | Biochemical Activity | [8] | |||
3 | Fluorescence Resonance Energy Transfer | [3] | |||
4 | Protein-peptide | [3] | |||
5 | Reconstituted Complex | [9] | |||
6 | Reconstituted Complex | [2] | |||
7 | Yeast two hybrid | [10] | |||
Interacting Protein Name | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | AGM7; GRB1; IMD36; p85; p85.ALPHA | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [2] | |||
2 | Affinity Capture-Western | [11] | |||
3 | Fluorescence Resonance Energy Transfer | [3] | |||
4 | Protein-peptide | [3] | |||
5 | Reconstituted Complex | [2] | |||
Interacting Target Name | Fyn tyrosine protein kinase (FYN) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Fyn Protooncogene Syn; Fyn p59-Fyn | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [12] | |||
2 | Biochemical Activity | [8] | |||
3 | Protein-peptide | [3] | |||
4 | Reconstituted Complex | [13] | |||
Interacting Target Name | LCK tyrosine protein kinase (LCK) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; LSK; Leukocyte C-terminal Src kinase; LCK Protooncogene Syn; LCK p59-Fyn | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [14] | |||
2 | Protein-peptide | [15] | |||
Interacting Target Name | Yes tyrosine kinase (YES) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Yes Protooncogene Syn; Yes p59-Fyn; Tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [3] | |||
2 | Biochemical Activity | [8] | |||
Interacting Target Name | Tyrosine-protein kinase Lyn (JTK8) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p56Lyn; p53Lyn; Lck/Yes-related novel protein tyrosine kinase | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [3] | |||
2 | Biochemical Activity | [8] | |||
Interacting Target Name | T-cell-specific kinase (ITK) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tyrosine-protein kinase Lyk; Tyrosine-protein kinase ITK/TSK; Tyrosine kinase ITK; LYK; Kinase EMT; Interleukin-2-inducible T-cell kinase; Inducible T cell kinase; IL-2-inducible T-cell kinase; EMT | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [16] | |||
2 | Reconstituted Complex | [17] | |||
One-carbon transferases | [+] 1 One-carbon transferases | + | |||
Interacting Target Name | Protein arginine methyltransferase 1 (PRMT1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein arginine N-methyltransferase 1; IR1B4; Interferon receptor 1-bound protein 4; HRMT1L2; HMT2; Histone-arginine N-methyltransferase PRMT1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [18] | |||
2 | Biochemical Activity | [19] | |||
Transcription regulators | [+] 1 Transcription regulators | + | |||
Interacting Target Name | CREB-binding protein (CREBBP) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CREBbinding protein; CBP | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [20] | |||
2 | Biochemical Activity | [21] | |||
3 | Reconstituted Complex | [20] | |||
4 | Yeast two hybrid | [20] | |||
Other proteins | [+] 4 Other proteins | + | |||
Interacting Target Name | GTPase activating protein (RASA1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RasGAP; RASA; Ras p21 protein activator; Ras GTPase-activating protein 1; p120GAP; GTPase-activating protein; GAP | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [22] | |||
2 | Affinity Capture-Western | [23] | |||
3 | Reconstituted Complex | [9] | |||
Interacting Protein Name | Apoptosis-stimulating of p53 protein 1 (PPP1R13B) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ASPP1; p53BP2.like; p85 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Far Western | [24] | |||
2 | Protein-peptide | [3] | |||
3 | Yeast two hybrid | [24] | |||
Interacting Protein Name | Heterogeneous nuclear ribonucleoprotein K (HNRNPK) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CSBP; HNRPK; TUNP | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Reconstituted Complex | [25] | |||
2 | Yeast two hybrid | [25] | |||
3 | Yeast two hybrid | [26] | |||
Interacting Protein Name | Sam68-like phosphotyrosine protein (KHDRBS3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Etle; SALP; SLM.2; SLM2; T.STAR; TSTAR; etoile | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Yeast two hybrid | [26] | |||
2 | Yeast two hybrid | [24] |
References | Top | ||||
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REF 1 | Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Nat Biotechnol. 2011 Jun 26;29(7):653-8. | ||||
REF 2 | Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src. Oncogene. 1999 Aug 19;18(33):4647-53. | ||||
REF 3 | Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. PLoS One. 2012;7(6):e38540. | ||||
REF 4 | A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5. | ||||
REF 5 | The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68. Oncogene. 1997 Jan 16;14(2):223-31. | ||||
REF 6 | Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor. Oncogene. 1997 Oct 9;15(15):1823-32. | ||||
REF 7 | CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation. J Immunol. 1997 Jan 1;158(1):94-103. | ||||
REF 8 | Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem. 2004 Aug 27;279(35):36259-67. | ||||
REF 9 | Multiple SH2-mediated interactions in v-src-transformed cells. Mol Cell Biol. 1992 Mar;12(3):1366-74. | ||||
REF 10 | A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68. | ||||
REF 11 | Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein. J Biol Chem. 1994 Apr 29;269(17):12503-7. | ||||
REF 12 | Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling. J Biol Chem. 1997 Mar 7;272(10):6214-9. | ||||
REF 13 | UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug. Oncogene. 2002 Mar 27;21(13):2037-50. | ||||
REF 14 | Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. EMBO Rep. 2006 Oct;7(10):1023-9. | ||||
REF 15 | Insights into human Lck SH3 domain binding specificity: different binding modes of artificial and native ligands. Biochemistry. 2005 Nov 15;44(45):15042-52. | ||||
REF 16 | The proline rich region of the Tec homology domain of ITK regulates its activity. FEBS Lett. 2002 Aug 14;525(1-3):53-8. | ||||
REF 17 | Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 1997 Jan 2;385(6611):93-7. | ||||
REF 18 | Arginine methylation regulates telomere length and stability. Mol Cell Biol. 2009 Sep;29(18):4918-34. | ||||
REF 19 | Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell. 2003 Jan;14(1):274-87. | ||||
REF 20 | Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68. Mol Cancer Res. 2002 Nov;1(1):48-55. | ||||
REF 21 | The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity. Oncogene. 2004 May 6;23(21):3781-9. | ||||
REF 22 | Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling. Mol Cell Endocrinol. 2001 Oct 25;183(1-2):113-21. | ||||
REF 23 | Sam68 association with p120GAP in CD4+ T cells is dependent on CD4 molecule expression. J Immunol. 1998 Sep 15;161(6):2798-803. | ||||
REF 24 | The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo. Oncogene. 2006 May 25;25(22):3104-12. | ||||
REF 25 | Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K. Oncogene. 2002 Oct 17;21(47):7187-94. | ||||
REF 26 | Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell. 2012 Feb 24;45(4):567-80. |
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