Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T80526 Target Info
Target Name Casein kinase II alpha prime (CSNK2A2)
Synonyms Casein kinase II subunit alpha'; CK2A2; CK II alpha'
Target Type Patented-recorded Target
Gene Name CSNK2A2
Biochemical Class Kinase
UniProt ID
CSK22_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 2 Kinases +
Interacting Protein Name Casein kinase II subunit beta (CSNK2B) Interacting Protein Interacting Protein Info
UniProt ID
CSK2B_HUMAN 
Synonyms CK2B; CK2N; CSK2B; G5A
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Biochemical Activity [4]
5 Biochemical Activity [5]
6 Biochemical Activity [6]
7 Co-fractionation [7]
8 Yeast two hybrid [8]
9 Yeast two hybrid [9]
10 Yeast two hybrid [10]
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-MS [12]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [2]
5 Affinity Capture-MS [3]
6 Affinity Capture-Western [5]
7 Co-fractionation [13]
8 Reconstituted Complex [14]
References  Top
REF 1 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 2 A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595.
REF 3 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 4 Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress. J Cell Sci. 2011 May 1;124(Pt 9):1519-32.
REF 5 Dependence of HSP27 cellular level on protein kinase CK2 discloses novel therapeutic strategies. Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2902-2910.
REF 6 Identification of a CK2 phosphorylation site in mdm2. Eur J Biochem. 1999 Dec;266(2):493-501.
REF 7 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 8 Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. J Biol Chem. 2000 May 12;275(19):14295-306.
REF 9 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 10 Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. PLoS Genet. 2013 Mar;9(3):e1003398.
REF 11 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 12 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 13 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 14 An AUTS2-Polycomb complex activates gene expression in the CNS. Nature. 2014 Dec 18;516(7531):349-54.

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