Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T80896 Target Info
Target Name Estrogen receptor beta (ESR2)
Synonyms Oestrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; NR3A2; Erbeta; ESTRB; ER-beta; Beta-1
Target Type Successful Target
Gene Name ESR2
Biochemical Class Nuclear hormone receptor
UniProt ID
ESR2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Proteasome 26S subunit ATPase 5 (PSMC5) Interacting Protein Interacting Protein Info
UniProt ID
PRS8_HUMAN 
Synonyms S8; SUG.1; SUG1; TBP10; TRIP1; p45; p45/SUG
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [2]
Acyltransferases [+] 4 Acyltransferases +
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Fluorescence Resonance Energy Transfer [5]
4 Fluorescence Resonance Energy Transfer [6]
5 Protein-peptide [7]
6 Reconstituted Complex [8]
7 Yeast two hybrid [9]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 6 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [5]
2 Fluorescence Resonance Energy Transfer [6]
3 Protein-peptide [7]
4 Reconstituted Complex [10]
5 Yeast two hybrid [2]
6 Yeast two hybrid [10]
Interacting Target Name Tripartite motif-containing 24 (TRIM24) Literature-reported Target Interacting Protein Info
UniProt ID
TIF1A_HUMAN 
Synonyms Tripartite motif-containing protein 24; Transcription intermediary factor 1-alpha; TIF1-alpha; TIF1A; TIF1; RNF82; RING-type E3 ubiquitin transferase TIF1-alpha; RING finger protein 82; E3 ubiquitin-protein ligase TRIM24
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
3 Fluorescence Resonance Energy Transfer [5]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Fluorescence Resonance Energy Transfer [5]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name DNA mismatch repair protein MSH2 (MSH2) Literature-reported Target Interacting Protein Info
UniProt ID
MSH2_HUMAN 
Synonyms MutS protein homolog 2; Mismatch repair gene Msh2; hMSH2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [12]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Protein Name Protein CASC3 (CASC3) Interacting Protein Interacting Protein Info
UniProt ID
CASC3_HUMAN 
Synonyms BTZ; MLN51
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [13]
Mediator complexes [+] 9 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [5]
2 Reconstituted Complex [14]
3 Reconstituted Complex [15]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 17 (MED17) Interacting Protein Interacting Protein Info
UniProt ID
MED17_HUMAN 
Synonyms CRSP6; CRSP77; DRIP80; TRAP80
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
3 Reconstituted Complex [15]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 14 (MED14) Interacting Protein Interacting Protein Info
UniProt ID
MED14_HUMAN 
Synonyms CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; RGR1; TRAP170
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [15]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 16 (MED16) Interacting Protein Interacting Protein Info
UniProt ID
MED16_HUMAN 
Synonyms DRIP92; THRAP5; TRAP95
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [15]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 20 (MED20) Interacting Protein Interacting Protein Info
UniProt ID
MED20_HUMAN 
Synonyms PRO0213; TRFP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [15]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 23 (MED23) Interacting Protein Interacting Protein Info
UniProt ID
MED23_HUMAN 
Synonyms ARC130; CRSP130; CRSP133; CRSP3; DRIP130; MRT18; SUR.2; SUR2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [15]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 24 (MED24) Interacting Protein Interacting Protein Info
UniProt ID
MED24_HUMAN 
Synonyms ARC100; CRSP100; CRSP4; DRIP100; THRAP4; TRAP100
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [15]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 4 (MED4) Interacting Protein Interacting Protein Info
UniProt ID
MED4_HUMAN 
Synonyms ARC36; DRIP36; HSPC126; TRAP36; VDRIP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 6 (MED6) Interacting Protein Interacting Protein Info
UniProt ID
MED6_HUMAN 
Synonyms ARC33; NY.REN.28
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [15]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [16]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [17]
4 Co-purification [3]
5 Reconstituted Complex [17]
6 Yeast two hybrid [18]
Ribosomal proteins [+] 5 Ribosomal proteins +
Interacting Protein Name Transformation-related gene 15 protein (PTCD3) Interacting Protein Interacting Protein Info
UniProt ID
PTCD3_HUMAN 
Synonyms MRP.S39
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
Interacting Protein Name Large ribosomal subunit protein eL42-like (RPL36AL) Interacting Protein Interacting Protein Info
UniProt ID
RL36L_HUMAN 
Synonyms RPL36A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
Interacting Protein Name Mitochondrial ribosomal protein S2 (MRPS2) Interacting Protein Interacting Protein Info
UniProt ID
RT02_HUMAN 
Synonyms MRP.S2; S2mt
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
Interacting Protein Name Mitochondrial ribosomal protein S22 (MRPS22) Interacting Protein Interacting Protein Info
UniProt ID
RT22_HUMAN 
Synonyms C3orf5; COXPD5; GIBT; MRP.S22; RPMS22
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
Interacting Protein Name mitochondrial ribosomal protein S27 (MRPS27) Interacting Protein Interacting Protein Info
UniProt ID
RT27_HUMAN 
Synonyms MRP.S27; S27mt
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 6 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [5]
2 Fluorescence Resonance Energy Transfer [6]
3 Protein-peptide [7]
4 Reconstituted Complex [10]
5 Yeast two hybrid [18]
6 Yeast two hybrid [10]
Interacting Protein Name Activating signal cointegrator 1 (TRIP4) Interacting Protein Interacting Protein Info
UniProt ID
TRIP4_HUMAN 
Synonyms ASC.1; ASC1; HsT17391; ZC2HC5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Fluorescence Resonance Energy Transfer [5]
Interacting Protein Name Zinc finger protein castor homolog 1 (CASZ1) Interacting Protein Interacting Protein Info
UniProt ID
CASZ1_HUMAN 
Synonyms CAS11; CST; SRG; ZNF693; dJ734G22.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [13]
Other proteins [+] 4 Other proteins +
Interacting Protein Name Nuclear receptor-interacting protein 1 (NRIP1) Interacting Protein Interacting Protein Info
UniProt ID
NRIP1_HUMAN 
Synonyms RIP140
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Fluorescence Resonance Energy Transfer [5]
3 Yeast two hybrid [2]
Interacting Protein Name Translocating chain-associated membrane protein 1 (TRAM1) Interacting Protein Interacting Protein Info
UniProt ID
TRAM1_HUMAN 
Synonyms PNAS8; TRAM; TRAMP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [10]
3 Yeast two hybrid [10]
Interacting Protein Name Protein LRATD2 (LRATD2) Interacting Protein Interacting Protein Info
UniProt ID
FA84B_HUMAN 
Synonyms BCMP101; NSE2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [13]
Interacting Protein Name Nuclear receptor coactivator 6 (NCOA6) Interacting Protein Interacting Protein Info
UniProt ID
NCOA6_HUMAN 
Synonyms AIB3; ASC2; NRC; PRIP; RAP250; TRBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [19]
2 Yeast two hybrid [2]
References  Top
REF 1 Quantitative mapping of RNA-mediated nuclear estrogen receptor interactome in human breast cancer cells. Sci Data. 2018 Mar 6;5:180031.
REF 2 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13.
REF 3 A large set of estrogen receptor -interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Proteomics. 2011 Jan;11(1):159-65.
REF 4 Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence. Endocr Relat Cancer. 2006 Dec;13(4):1135-45.
REF 5 Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres. Cytometry. 2001 Aug 1;44(4):326-37.
REF 6 Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells. Mol Endocrinol. 2003 Apr;17(4):589-99.
REF 7 Ligands specify coactivator nuclear receptor (NR) box affinity for estrogen receptor subtypes. Mol Endocrinol. 2001 Jun;15(6):909-22.
REF 8 Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands. Biochemistry. 2001 Jun 12;40(23):6756-65.
REF 9 A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity. J Biol Chem. 1998 Oct 16;273(42):27645-53.
REF 10 Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology. 2000 Oct;141(10):3534-45.
REF 11 Estrogen receptor (ER) beta or p53 attenuates ERalpha-mediated transcriptional activation on the BRCA2 promoter. J Biol Chem. 2008 Oct 31;283(44):29671-80.
REF 12 The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha. Br J Cancer. 2005 Jun 20;92(12):2286-91.
REF 13 Systematic identification of molecular links between core and candidate genes in breast cancer. J Mol Biol. 2015 Mar 27;427(6 Pt B):1436-1450.
REF 14 Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. J Biol Chem. 2000 Jul 7;275(27):20928-34.
REF 15 The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2642-7.
REF 16 The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin. Mol Endocrinol. 2008 Feb;22(2):304-16.
REF 17 The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro. Biochem Biophys Res Commun. 1998 Feb 4;243(1):122-6.
REF 18 Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic ce... J Endocrinol. 2003 Mar;176(3):349-57.
REF 19 Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Mol Endocrinol. 2002 Jan;16(1):128-40.

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