Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T80975 Target Info
Target Name Vascular endothelial growth factor receptor 2 (KDR)
Synonyms VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309
Target Type Successful Target
Gene Name KDR
Biochemical Class Kinase
UniProt ID
VGFR2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Far Western [3]
3 Yeast two hybrid [4]
Interacting Target Name Protein-tyrosine phosphatase SHP-1 (PTPN6) Patented-recorded Target Interacting Protein Info
UniProt ID
PTN6_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; PTP-1C; PTP1C; Protein-tyrosine phosphatase 1C; Hematopoietic cell protein-tyrosine phosphatase; HCP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Co-localization [5]
3 Yeast two hybrid [4]
Growth factors [+] 1 Growth factors +
Interacting Target Name Vascular endothelial growth factor A (VEGFA) Successful Target Interacting Protein Info
UniProt ID
VEGFA_HUMAN 
Synonyms VPF; VEGF-A; VEGF; Vascular permeability factor; Vascular endothelial growth factor A
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [6]
2 Co-localization [7]
3 Reconstituted Complex [8]
Kinases [+] 1 Kinases +
Interacting Target Name Vascular endothelial growth factor receptor 1 (FLT-1) Successful Target Interacting Protein Info
UniProt ID
VGFR1_HUMAN 
Synonyms VEGFR-1; VEGFR1; VEGF-1 receptor; Vascular permeability factor receptor; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; FRT; Fms-like tyrosine kinase 1; FLT
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [10]
Other proteins [+] 1 Other proteins +
Interacting Protein Name SHC-transforming protein 2 (SHC2) Interacting Protein Interacting Protein Info
UniProt ID
SHC2_HUMAN 
Synonyms SCK; SHCB; SLI
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [11]
3 Yeast two hybrid [12]
4 Yeast two hybrid [13]
References  Top
REF 1 Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-B Pathway Via Actin and Tyrosine Kinases. Cell Mol Bioeng. 2009 Sep 1;2(3):341-350.
REF 2 A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5413-8.
REF 3 Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1. Circ Res. 2006 Jan 6;98(1):45-54.
REF 4 A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017 Jan 19;65(2):347-360.
REF 5 TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation. FASEB J. 2017 May;31(5):2001-2012.
REF 6 ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem. 2003 Jun 27;278(26):23656-65.
REF 7 Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor. Mol Cancer. 2015 Feb 3;14:19.
REF 8 Distinct heparin binding sites on VEGF165 and its receptors revealed by their interaction with a non sulfated glycoaminoglycan (NaPaC). Biochim Biophys Acta. 2008 Apr;1780(4):723-32.
REF 9 N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain. PLoS One. 2014 Nov 11;9(11):e112794.
REF 10 Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med. 2003 Jul;9(7):936-43.
REF 11 Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling. Oncogene. 2002 Sep 12;21(41):6307-16.
REF 12 The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells. Biochem J. 2000 Apr 15;347(Pt 2):501-9.
REF 13 Sck interacts with KDR and Flt-1 via its SH2 domain. Biochem Biophys Res Commun. 1998 Oct 9;251(1):77-82.

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