Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T82393 Target Info
Target Name TNF alpha converting enzyme (ADAM17)
Synonyms TNFalpha converting enzyme; TNF-alpha-converting enzyme; TNF-alpha converting enzyme; TNF-alpha convertase; TACE; Snake venom-like protease; Disintegrin and metalloproteinase domain-containing protein 17; CSVP; CD156b antigen; CD156b; ADAM 17; A disintegrin and metalloproteinase domain 17
Target Type Clinical trial Target
Gene Name ADAM17
Biochemical Class Peptidase
UniProt ID
ADA17_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Disks large homolog 1 (DLG1) Interacting Protein Interacting Protein Info
UniProt ID
DLG1_HUMAN 
Synonyms DLGH1; SAP.97; SAP97; dJ1061C18.1.1; hdlg
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [1]
4 Yeast two hybrid [2]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) Interacting Protein Interacting Protein Info
UniProt ID
MD2L1_HUMAN 
Synonyms HSMAD2; MAD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
References  Top
REF 1 DLG1/SAP97 modulates transforming growth factor alpha bioavailability. Biochim Biophys Acta. 2009 Feb;1793(2):264-72.
REF 2 Identification of SAP97 as an intracellular binding partner of TACE. J Cell Sci. 2003 May 15;116(Pt 10):1949-57.
REF 3 Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. J Biol Chem. 2002 Feb 15;277(7):4999-5007.
REF 4 Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. Biochem J. 1999 Nov 1;343 Pt 3:673-80.

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