Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T83174 Target Info
Target Name Protein kinase C iota (PRKCI)
Synonyms nPKC-iota; aPKC-lambda/iota; Protein kinase C iota type; PRKC-lambda/iota; DXS1179E; Atypical protein kinase C-lambda/iota
Target Type Literature-reported Target
Gene Name PRKCI
Biochemical Class Kinase
UniProt ID
KPCI_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 4 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Co-fractionation [4]
5 Co-localization [5]
6 Fluorescence Resonance Energy Transfer [6]
7 Protein-peptide [6]
8 Reconstituted Complex [4]
9 Yeast two hybrid [4]
Interacting Protein Name Partitioning defective 6 homolog alpha (PARD6A) Interacting Protein Interacting Protein Info
UniProt ID
PAR6A_HUMAN 
Synonyms PAR.6A; PAR6; PAR6C; PAR6alpha; TAX40; TIP.40
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [7]
3 Yeast two hybrid [8]
4 Yeast two hybrid [9]
5 Yeast two hybrid [10]
6 Yeast two hybrid [3]
Interacting Protein Name Partitioning defective 6 homolog beta (PARD6B) Interacting Protein Interacting Protein Info
UniProt ID
PAR6B_HUMAN 
Synonyms PAR6B
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [11]
3 Affinity Capture-Western [12]
4 Affinity Capture-Western [13]
5 Yeast two hybrid [9]
Interacting Protein Name Partitioning defective 6 homolog gamma (PARD6G) Interacting Protein Interacting Protein Info
UniProt ID
PAR6G_HUMAN 
Synonyms PAR.6G; PAR6gamma
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [14]
Kinases [+] 1 Kinases +
Interacting Protein Name MAP/microtubule affinity-regulating kinase 4 (MARK4) Interacting Protein Interacting Protein Info
UniProt ID
MARK4_HUMAN 
Synonyms MARK4L; MARK4S; MARKL1; MARKL1L; PAR.1D
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [15]
References  Top
REF 1 Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J Biol Chem. 2004 Mar 26;279(13):12804-11.
REF 2 NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo. EMBO J. 2010 Oct 6;29(19):3421-33.
REF 3 Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. J Biol Chem. 2003 Sep 5;278(36):34568-81.
REF 4 Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol. 1998 May;18(5):3069-80.
REF 5 Sequestosome 1 protects esophageal squamous carcinoma cells from apoptosis via stabilizing SKP2 under serum starvation condition. Oncogene. 2018 Jun;37(24):3260-3274.
REF 6 Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 4;290(36):21845-56.
REF 7 Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota. J Biol Chem. 2006 Sep 22;281(38):28450-9.
REF 8 Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol. 2001 Mar 19;152(6):1183-96.
REF 9 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 10 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 11 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 12 The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells. J Cell Biol. 2013 Mar 4;200(5):635-50.
REF 13 Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. J Proteome Res. 2013 Jul 5;12(7):3181-92.
REF 14 rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Nat Commun. 2018 Sep 14;9(1):3747.
REF 15 Atypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro. Mol Cell Biochem. 2015 Dec;410(1-2):223-8.

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