Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T84703 Target Info
Target Name BDNF/NT-3 growth factors receptor (TrkB)
Synonyms Tropomyosin-related kinase B; TrkB tyrosine kinase; Trk-B; TRKB; Neurotrophic tyrosine kinase receptor type 2; GP145-TrkB
Target Type Successful Target
Gene Name NTRK2
Biochemical Class Kinase
UniProt ID
NTRK2_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase 1B (PTP1B) Clinical trial Target Interacting Protein Info
UniProt ID
PTN1_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 1; PTP-1B
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [1]
2 Reconstituted Complex [2]
Growth factors [+] 1 Growth factors +
Interacting Target Name Neurotrophin-4 (NTF4) Literature-reported Target Interacting Protein Info
UniProt ID
NTF4_HUMAN 
Synonyms NTF5; NT-5; NT-4; NT4; Neutrophic factor 4; Neurotrophin-5; Neurotrophin5; Neurotrophin4
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [3]
2 Reconstituted Complex [4]
Kinases [+] 1 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [5]
2 Yeast two hybrid [6]
References  Top
REF 1 The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities. Protein Sci. 2002 Oct;11(10):2326-34.
REF 2 Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling. J Biol Chem. 2014 Nov 14;289(46):31682-92.
REF 3 Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure. 2001 Dec;9(12):1191-9.
REF 4 A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4. Biochem Biophys Res Commun. 2002 Mar 1;291(3):501-7.
REF 5 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 6 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.

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