Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T85554 Target Info
Target Name T-cell activation antigen CD27 (CD27)
Synonyms Tumor necrosis factor receptor superfamily member 7; Tcell activation antigen CD27; TNFRSF7; T14; CD27L receptor; CD27 antigen
Target Type Clinical trial Target
Gene Name CD27
Biochemical Class Cytokine receptor
UniProt ID
CD27_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Yeast two hybrid [5]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Apoptosis regulatory protein Siva (SIVA1) Interacting Protein Interacting Protein Info
UniProt ID
SIVA_HUMAN 
Synonyms CD27BP; SIVA; Siva.1; Siva.2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Yeast two hybrid [6]
3 Yeast two hybrid [7]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of ... J Immunol. 1998 Nov 1;161(9):4753-9.
REF 4 CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. J Biol Chem. 1998 May 22;273(21):13353-8.
REF 5 The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2. Eur J Immunol. 1998 Jul;28(7):2208-16.
REF 6 CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6346-51.
REF 7 The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22. Mol Cell Biochem. 2006 Jul;287(1-2):147-55.

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