Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86130 | Target Info | |||
| Target Name | Integrin alpha-4/beta-1 (ITGA4/B1) | ||||
| Synonyms | alpha(4)beta(1) integrin; Alpha 4 beta 1 integrin | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ITGA4-ITGB1 | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Auxiliary transporters | [+] 1 Auxiliary transporters | + | |||
| Interacting Target Name | Filamin A (FLNA) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Non-muscle filamin; Nonmuscle filamin; FLN-A; FLN1; FLN; Filamin-A; Filamin-1; Filamin 1; Endothelial actin-binding protein; Endothelial actin cytoskeleton; Alpha-filamin; Actin-binding protein 280; ABP-280 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Reconstituted Complex | [2] | |||
| 3 | Yeast two hybrid | [1] | |||
| Integrins | [+] 2 Integrins | + | |||
| Interacting Target Name | Integrin alpha-5 (ITGA5) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | VLA-5; Integrin alpha-F; Integrin alpha-5 light chain; Integrin alpha-5 heavy chain; FNRA; Fibronectin receptor subunit alpha; CD49e antigen; CD49e; CD49 antigen-like family member E | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Reconstituted Complex | [4] | |||
| Interacting Protein Name | Integrin alpha-3 (ITGA3) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CD49C; GAP.B3; GAPB3; ILNEB; MSK18; VCA.2; VL3A; VLA3a | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Reconstituted Complex | [6] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | Talin-1 (TLN1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | TLN; Talin-1; KIAA1027 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Co-fractionation | [7] | |||
| 2 | Protein-peptide | [8] | |||
| 3 | Reconstituted Complex | [9] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction. J Biol Chem. 1998 Sep 4;273(36):23304-12. | ||||
| REF 2 | Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol. 2002 Jan 21;156(2):361-76. | ||||
| REF 3 | Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell. 2010 Jul 20;19(1):148-59. | ||||
| REF 4 | Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with 51 integrin. J Biol Chem. 2014 Nov 7;289(45):31330-40. | ||||
| REF 5 | Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. Oncogene. 2007 Jan 18;26(3):382-94. | ||||
| REF 6 | Cross-talk of integrin alpha3beta1 and tissue factor in cell migration. Mol Biol Cell. 2004 Oct;15(10):4416-25. | ||||
| REF 7 | A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81. | ||||
| REF 8 | Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J Biol Chem. 2001 Jun 15;276(24):21217-27. | ||||
| REF 9 | Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. J Biol Chem. 2009 Dec 25;284(52):36700-10. | ||||
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