Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T89056 Target Info
Target Name Platelet endothelial cell adhesion molecule (PECAM1)
Synonyms PECAM-1; PECA1; GPIIA'; EndoCAM; ECAM; CD31 antigen; CD31
Target Type Literature-reported Target
Gene Name PECAM1
UniProt ID
PECA1_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Far Western [4]
5 Reconstituted Complex [4]
6 Reconstituted Complex [2]
7 Reconstituted Complex [3]
Interacting Target Name Protein-tyrosine phosphatase SHP-1 (PTPN6) Patented-recorded Target Interacting Protein Info
UniProt ID
PTN6_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; PTP-1C; PTP1C; Protein-tyrosine phosphatase 1C; Hematopoietic cell protein-tyrosine phosphatase; HCP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Far Western [4]
3 Reconstituted Complex [4]
4 Reconstituted Complex [2]
Other proteins [+] 1 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [5]
References  Top
REF 1 Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation. J Biol Chem. 2000 Jul 14;275(28):21435-43.
REF 2 Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates. J Biol Chem. 1998 Oct 23;273(43):28332-40.
REF 3 The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling. J Biol Chem. 1997 Mar 14;272(11):6986-93.
REF 4 Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31. FEBS Lett. 1999 Apr 30;450(1-2):77-83.
REF 5 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.

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