Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T92144 Target Info
Target Name Angiopoietin 1 receptor (TEK)
Synonyms hTIE2; VMCM1; VMCM; Tyrosine-protein kinase receptor TIE-2; Tyrosine-protein kinase receptor TEK; Tyrosine kinase with Ig and EGF homology domains-2; Tunica interna endothelial cell kinase; TIE2; P140 TEK; Endothelial tyrosine kinase; Endothelial Cell-Specific Receptor TIE-2; CD202b antigen; CD202b
Target Type Clinical trial Target
Gene Name TEK
Biochemical Class Kinase
UniProt ID
TIE2_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 2 Other proteins +
Interacting Target Name Angiopoietin-1 (ANGPT1) Clinical trial Target Interacting Protein Info
UniProt ID
ANGP1_HUMAN 
Synonyms ANGPT1; Angiopoietin1; ANG-1; ANG1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
3 Reconstituted Complex [2]
4 Reconstituted Complex [3]
5 Reconstituted Complex [4]
Interacting Target Name Angiopoietin-2 (ANGPT2) Successful Target Interacting Protein Info
UniProt ID
ANGP2_HUMAN 
Synonyms ANG-2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
References  Top
REF 1 Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J Biol Chem. 2003 Jan 17;278(3):1721-7.
REF 2 Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell. 1996 Dec 27;87(7):1161-9.
REF 3 Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 1998 Aug;10(8):1217-27.
REF 4 Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science. 1997 Jul 4;277(5322):55-60.

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