Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T94197 Target Info
Target Name Protein kinase N2 (PKN2)
Synonyms Serine/threonine-protein kinase N2; Protein-kinase C-related kinase 2; Protein kinase C-like 2; PRKCL2; PRK2; PKN gamma
Target Type Literature-reported Target
Gene Name PKN2
Biochemical Class Kinase
UniProt ID
PKN2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Transforming protein RhoA (RHOA) Discontinued Target Interacting Protein Info
UniProt ID
RHOA_HUMAN 
Synonyms Transforming protein RhoA; RHO12; Rho cDNA clone 12; h12; ARHA; ARH12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name NCK adaptor protein 1 (NCK1) Clinical trial Target Interacting Protein Info
UniProt ID
NCK1_HUMAN 
Synonyms SH2/SH3 adaptor protein NCK-alpha; SH2/SH3 adaptor protein NCKalpha; Nck-1; Nck1; NCK; Cytoplasmic protein NCK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [2]
Kinases [+] 1 Kinases +
Interacting Target Name Phosphoinositide dependent protein kinase-1 (PDPK1) Clinical trial Target Interacting Protein Info
UniProt ID
PDPK1_HUMAN 
Synonyms PDK1; HPDK1; 3-phosphoinositide-dependent protein kinase 1; 3-Phosphoinositide-dependent kinase-1; 3'-phosphoinositide dependent kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Yeast two hybrid [5]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J Biol Chem. 1996 Nov 15;271(46):28772-6.
REF 3 Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. J Biol Chem. 1999 Feb 26;274(9):5542-9.
REF 4 Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. Biochemistry. 2002 Jan 15;41(2):561-9.
REF 5 A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1. J Biol Chem. 2000 Jul 7;275(27):20806-13.

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