Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T94479 Target Info
Target Name Ribosomal protein S6 kinase beta-1 (S6K1)
Synonyms p70-S6K 1; p70 ribosomal S6 kinase alpha; p70 S6KA; p70 S6K-alpha; p70 S6 kinase alpha; Serine/threonine-protein kinase 14A; STK14A; S6K-beta-1; S6K; Ribosomal protein S6 kinase I; P70S6K1; P70-S6K; 70 kDa ribosomal protein S6 kinase 1
Target Type Clinical trial Target
Gene Name RPS6KB1
Biochemical Class Kinase
UniProt ID
KS6B1_HUMAN 
Target Interacting Proteins  Top
Eukaryotic initiation factors [+] 1 Eukaryotic initiation factors +
Interacting Protein Name Eukaryotic translation initiation factor 3 subunit B (EIF3B) Interacting Protein Interacting Protein Info
UniProt ID
EIF3B_HUMAN 
Synonyms EIF3.ETA; EIF3.P110; EIF3.P116; EIF3S9; PRT1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
Kinases [+] 2 Kinases +
Interacting Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target Interacting Protein Info
UniProt ID
MTOR_HUMAN 
Synonyms TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
5 Biochemical Activity [7]
6 Reconstituted Complex [5]
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [8]
3 Yeast two hybrid [9]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Eukaryotic translation initiation factor 3 subunit F (EIF3F) Interacting Protein Interacting Protein Info
UniProt ID
EIF3F_HUMAN 
Synonyms EIF3S5; eIF3.p47
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Other proteins [+] 2 Other proteins +
Interacting Target Name Insulin receptor substrate-1 (IRS1) Clinical trial Target Interacting Protein Info
UniProt ID
IRS1_HUMAN 
Synonyms IRS-1; Insulin receptor substrate 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [10]
2 Biochemical Activity [11]
3 Reconstituted Complex [10]
Interacting Target Name MTOR complex 2 (RICTOR) Literature-reported Target Interacting Protein Info
UniProt ID
RICTR_HUMAN 
Synonyms Rapamycin-insensitive companion of mTOR; KIAA1999; hAVO3; AVO3 homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [12]
2 Reconstituted Complex [13]
References  Top
REF 1 mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell. 2005 Nov 18;123(4):569-80.
REF 2 Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase. Mol Cell Biol. 2014 Mar;34(6):1046-53.
REF 3 Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem. 2005 Jul 8;280(27):25485-90.
REF 4 Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002 Jul 26;110(2):177-89.
REF 5 Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem. 2005 Jul 15;280(28):26089-93.
REF 6 The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation. J Biol Chem. 2005 May 20;280(20):19937-47.
REF 7 The FRB domain of mTOR: NMR solution structure and inhibitor design. Biochemistry. 2006 Aug 29;45(34):10294-302.
REF 8 Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation. Biochim Biophys Acta. 2013 Dec;1832(12):1980-8.
REF 9 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 10 Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination. J Biol Chem. 2012 Nov 23;287(48):40758-66.
REF 11 The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell. 2008 May 23;30(4):403-14.
REF 12 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 13 Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem. 2005 May 20;280(20):19445-8.

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