Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T97155 Target Info
Target Name Serine/threonine-protein kinase ATR (FRP1)
Synonyms FRAP-related protein 1; Ataxia telangiectasia and Rad3-related protein
Target Type Clinical trial Target
Gene Name ATR
Biochemical Class Kinase
UniProt ID
ATR_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Werner syndrome ATP-dependent helicase (WRN) Interacting Protein Interacting Protein Info
UniProt ID
WRN_HUMAN 
Synonyms RECQ3; RECQL2; RECQL3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Protein-peptide [3]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Biochemical Activity [4]
4 Biochemical Activity [6]
5 Biochemical Activity [5]
6 Protein-peptide [3]
7 Reconstituted Complex [6]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name DNA mismatch repair protein MSH2 (MSH2) Literature-reported Target Interacting Protein Info
UniProt ID
MSH2_HUMAN 
Synonyms MutS protein homolog 2; Mismatch repair gene Msh2; hMSH2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [7]
4 Co-localization [7]
5 Reconstituted Complex [8]
Histones [+] 1 Histones +
Interacting Target Name Gamma-Histone H2AX (H2AFX) Literature-reported Target Interacting Protein Info
UniProt ID
H2AX_HUMAN 
Synonyms Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2AX; H2a/x
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [9]
2 Co-localization [10]
Kinases [+] 3 Kinases +
Interacting Target Name Checkpoint kinase-1 (CHK1) Clinical trial Target Interacting Protein Info
UniProt ID
CHK1_HUMAN 
Synonyms Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Chk1; Cell cycle checkpoint kinase
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [12]
3 Biochemical Activity [13]
4 Biochemical Activity [14]
5 Biochemical Activity [15]
6 Protein-peptide [3]
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Protein-peptide [3]
Interacting Target Name ATM serine/threonine kinase (ATM) Clinical trial Target Interacting Protein Info
UniProt ID
ATM_HUMAN 
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [17]
2 Protein-peptide [3]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [18]
3 Biochemical Activity [16]
4 Biochemical Activity [3]
5 Biochemical Activity [19]
6 Biochemical Activity [20]
7 Protein-peptide [3]
8 Reconstituted Complex [21]
Other proteins [+] 5 Other proteins +
Interacting Protein Name ATR-interacting protein (ATRIP) Interacting Protein Interacting Protein Info
UniProt ID
ATRIP_HUMAN 
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-MS [7]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [23]
5 Affinity Capture-Western [22]
6 Affinity Capture-Western [24]
7 Affinity Capture-Western [25]
8 Affinity Capture-Western [26]
9 Affinity Capture-Western [27]
10 Affinity Capture-Western [28]
11 Affinity Capture-Western [29]
12 Biochemical Activity [22]
13 Biochemical Activity [26]
14 Co-fractionation [30]
15 Co-fractionation [14]
Interacting Protein Name Cell cycle checkpoint protein RAD17 (RAD17) Interacting Protein Interacting Protein Info
UniProt ID
RAD17_HUMAN 
Synonyms CCYC; HRAD17; R24L; RAD17SP; RAD24
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Affinity Capture-Western [32]
3 Biochemical Activity [31]
4 Biochemical Activity [30]
5 Protein-peptide [3]
Interacting Protein Name Fanconi anemia group D2 protein (FANCD2) Interacting Protein Interacting Protein Info
UniProt ID
FACD2_HUMAN 
Synonyms FA.D2; FA4; FACD; FAD; FAD2; FANCD
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [33]
2 Biochemical Activity [34]
3 Co-localization [35]
Interacting Protein Name Replication factor A protein 1 (RPA1) Interacting Protein Interacting Protein Info
UniProt ID
RFA1_HUMAN 
Synonyms HSSB; MST075; REPA1; RF.A; RP.A; RPA70
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Protein-peptide [3]
Interacting Protein Name DNA repair protein complementing XP-C cells (XPC) Interacting Protein Interacting Protein Info
UniProt ID
XPC_HUMAN 
Synonyms RAD4; XP3; XPCC; p125
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Co-localization [10]
References  Top
REF 1 Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci. 2006 Dec 15;119(Pt 24):5137-46.
REF 2 WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes. J Cell Sci. 2011 Dec 1;124(Pt 23):3967-79.
REF 3 Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem. 1999 Dec 31;274(53):37538-43.
REF 4 Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res. 2000 Sep 15;60(18):5037-9.
REF 5 Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J Biol Chem. 2001 May 18;276(20):17276-80.
REF 6 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 2000 Dec 1;14(23):2989-3002.
REF 7 hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J Biol Chem. 2011 Mar 25;286(12):10411-8.
REF 8 MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15387-92.
REF 9 Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Mol Cell Biol. 2012 Feb;32(4):783-96.
REF 10 Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation. Mol Cell Biol. 2009 Dec;29(23):6206-19.
REF 11 Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 2005 Mar 23;24(6):1157-69.
REF 12 Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage. Mol Cancer Ther. 2011 Jul;10(7):1194-206.
REF 13 Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. Oncogene. 2009 May 7;28(18):1971-81.
REF 14 Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13301-6.
REF 15 ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol. 2001 Jul;21(13):4129-39.
REF 16 A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death Differ. 2011 Jan;18(1):5-15.
REF 17 ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J. 2006 Dec 13;25(24):5775-82.
REF 18 Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001 Jul 15;15(14):1833-44.
REF 19 The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53. Oncogene. 1999 Jul 8;18(27):3989-95.
REF 20 DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J Biol Chem. 2006 Jan 20;281(3):1692-7.
REF 21 BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem. 2004 Jul 23;279(30):31251-8.
REF 22 ATR and ATRIP: partners in checkpoint signaling. Science. 2001 Nov 23;294(5547):1713-6.
REF 23 Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature. 2005 Mar 31;434(7033):605-11.
REF 24 HCLK2 is required for activity of the DNA damage response kinase ATR. J Biol Chem. 2009 Feb 13;284(7):4140-7.
REF 25 Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev. 2008 Mar 1;22(5):587-600.
REF 26 ATR-dependent phosphorylation of ATRIP in response to genotoxic stress. Biochem Biophys Res Commun. 2004 Oct 29;323(4):1197-202.
REF 27 ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem. 2008 Mar 7;283(10):6572-83.
REF 28 HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nat Cell Biol. 2007 Apr;9(4):391-401.
REF 29 Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19304-9.
REF 30 A novel protein activity mediates DNA binding of an ATR-ATRIP complex. J Biol Chem. 2004 Apr 2;279(14):13346-53.
REF 31 ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature. 2001 Jun 21;411(6840):969-74.
REF 32 Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. EMBO J. 2010 May 19;29(10):1726-37.
REF 33 Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol. 2006 Sep;26(18):7005-15.
REF 34 ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway. Cancer Res. 2012 Mar 1;72(5):1149-56.
REF 35 The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J. 2004 Mar 10;23(5):1178-87.
REF 36 NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites. DNA Repair (Amst). 2013 Apr 1;12(4):273-83.

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