Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T97589 Target Info
Target Name Apoptosis signal-regulating kinase 1 (MAP3K5)
Synonyms Mitogen-activated protein kinase kinase kinase 5; MEKK5; MEKK 5; MEK kinase 5; MAPKKK5; MAPK/ERK kinase kinase 5; ASK1; ASK-1
Target Type Clinical trial Target
Gene Name MAP3K5
Biochemical Class Kinase
UniProt ID
M3K5_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Kinases [+] 6 Kinases +
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) Interacting Protein Interacting Protein Info
UniProt ID
MP2K6_HUMAN 
Synonyms MAPKK6; MEK6; MKK6; PRKMK6; SAPKK.3; SAPKK3
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [3]
2 Biochemical Activity [4]
3 Biochemical Activity [5]
4 Reconstituted Complex [6]
Interacting Target Name TGF-beta-activated kinase 1 (MAP3K7) Literature-reported Target Interacting Protein Info
UniProt ID
M3K7_HUMAN 
Synonyms Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Yeast two hybrid [7]
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) Interacting Protein Interacting Protein Info
UniProt ID
MP2K4_HUMAN 
Synonyms JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK.1; SAPKK1; SEK1; SERK1; SKK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [10]
3 Biochemical Activity [11]
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 2 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [12]
2 Reconstituted Complex [13]
Interacting Target Name Apoptosis signal-regulating kinase 2 (MAP3K6) Literature-reported Target Interacting Protein Info
UniProt ID
M3K6_HUMAN 
Synonyms MAP3K6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [3]
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) Interacting Protein Interacting Protein Info
UniProt ID
MP2K3_HUMAN 
Synonyms MAPKK3; MEK3; MKK3; PRKMK3; SAPKK.2; SAPKK2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Co-fractionation [15]
Other proteins [+] 5 Other proteins +
Interacting Target Name Thioredoxin (TXN) Clinical trial Target Interacting Protein Info
UniProt ID
THIO_HUMAN 
Synonyms TRX1; Trx; TRDX; Surface-associated sulphydryl protein; Surface associated sulphydryl protein; SASP; ATL-derived factor; ADF
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Affinity Capture-Western [14]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [17]
5 Affinity Capture-Western [18]
6 Affinity Capture-Western [19]
7 Reconstituted Complex [20]
8 Yeast two hybrid [21]
9 Yeast two hybrid [22]
Interacting Protein Name C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3) Interacting Protein Interacting Protein Info
UniProt ID
JIP3_HUMAN 
Synonyms JIP3; JSAP1; SYD2; syd
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Affinity Capture-Western [10]
3 Biochemical Activity [23]
Interacting Protein Name Small integral membrane protein 40 (SMIM40) Interacting Protein Interacting Protein Info
UniProt ID
SIM40_HUMAN 
Synonyms BING2; DAP6; EAP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Affinity Capture-Western [25]
3 Co-localization [26]
Interacting Target Name Beta-arrestin-1 (ARRB1) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB1_HUMAN 
Synonyms Non-visual arrestin-2; Betaarrestin1; Arrestin beta-1; Arrestin beta1; ARR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Protein-peptide [28]
Interacting Target Name Suppressor of cytokine signaling 1 (SOCS1) Literature-reported Target Interacting Protein Info
UniProt ID
SOCS1_HUMAN 
Synonyms TIP-3; TIP3; Tec-interacting protein 3; STAT-induced STAT inhibitor 1; STAT induced STAT inhibitor 1; SSI-1; SSI1; SOCS-1; JAK-binding protein; JAB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Reconstituted Complex [29]
References  Top
REF 1 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 2 Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8511-5.
REF 3 Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J. 2001 Nov 1;20(21):6028-36.
REF 4 DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. J Cell Biochem. 2010 May;110(1):229-37.
REF 5 CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation. Mol Cell Biochem. 2014 Dec;397(1-2):139-46.
REF 6 Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). Mol Cell. 2003 Jun;11(6):1491-501.
REF 7 ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction. J Biol Chem. 2000 Oct 20;275(42):32747-52.
REF 8 Reciprocal inhibition between the transforming growth factor--activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein kinase kinase kinases and its suppression by TAK1-binding protein 2 (TAB2), an adapter protein for TAK1. J Biol Chem. 2012 Jan 27;287(5):3381-91.
REF 9 Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5. Cell Death Differ. 2007 Aug;14(8):1518-28.
REF 10 Daxx deletion mutant (amino acids 501-625)-induced apoptosis occurs through the JNK/p38-Bax-dependent mitochondrial pathway. J Cell Biochem. 2004 Aug 15;92(6):1257-70.
REF 11 AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem. 2004 Oct 22;279(43):44955-65.
REF 12 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 13 Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7783-8.
REF 14 CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17389-94.
REF 15 Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. J Immunol. 2006 Jun 1;176(11):7039-50.
REF 16 Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1. J Biol Chem. 2007 May 4;282(18):13680-91.
REF 17 DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex. Neurosci Res. 2010 Jul;67(3):203-8.
REF 18 Overexpression of thioredoxin-binding protein 2 increases oxidation sensitivity and apoptosis in human lens epithelial cells. Free Radic Biol Med. 2013 Apr;57:92-104.
REF 19 Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells. J Clin Invest. 2005 Mar;115(3):733-8.
REF 20 Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner. Circ Res. 2002 Jun 28;90(12):1259-66.
REF 21 Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 1998 May 1;17(9):2596-606.
REF 22 Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. Mol Cell Biol. 2007 Dec;27(23):8152-63.
REF 23 Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. J Biol Chem. 2002 Oct 25;277(43):40703-9.
REF 24 Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science. 1998 Sep 18;281(5384):1860-3.
REF 25 Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. J Biol Chem. 2001 Oct 19;276(42):39103-6.
REF 26 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 27 beta-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis. Cell Signal. 2009 Jul;21(7):1195-206.
REF 28 A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. FEBS Lett. 2009 Oct 20;583(20):3310-6.
REF 29 SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation. J Biol Chem. 2006 Mar 3;281(9):5559-66.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.