Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T98337 Target Info
Target Name FK506-binding protein 5 (FKBP5)
Synonyms Peptidyl-prolyl cis-trans isomerase FKBP5; PPIase FKBP5; HSP90-binding immunophilin; FKBP54; FKBP51; FKBP-51; FKBP-5; FF1 antigen; Androgen-regulated protein 6; AIG6; 54 kDa progesterone receptor-associated immunophilin; 51 kDa FKBP; 51 kDa FK506-binding protein
Target Type Literature-reported Target
Gene Name FKBP5
Biochemical Class Cis-trans-isomerase
UniProt ID
FKBP5_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Protein argonaute-1 (AGO1) Interacting Protein Interacting Protein Info
UniProt ID
AGO1_HUMAN 
Synonyms EIF2C; EIF2C1; GERP95; Q99
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
4 Affinity Capture-Western [3]
5 Co-fractionation [4]
6 Reconstituted Complex [3]
7 Reconstituted Complex [5]
8 Reconstituted Complex [6]
9 Reconstituted Complex [7]
Kinases [+] 2 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [8]
Interacting Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target Interacting Protein Info
UniProt ID
CDK9_HUMAN 
Synonyms Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2-related kinase; CDC2L4; C-2K
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Reconstituted Complex [10]
Other proteins [+] 1 Other proteins +
Interacting Protein Name NudC domain-containing protein 3 (NUDCD3) Interacting Protein Interacting Protein Info
UniProt ID
NUDC3_HUMAN 
Synonyms NudCL
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
References  Top
REF 1 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014 Jul 17;158(2):434-448.
REF 2 USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling. EMBO J. 2017 May 15;36(10):1434-1446.
REF 3 Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. Mol Cell Biol. 1997 Feb;17(2):594-603.
REF 4 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 5 Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle. Nat Struct Mol Biol. 2011 Jan;18(1):61-6.
REF 6 Quantitative assessment of complex formation of nuclear-receptor accessory proteins. Biochem J. 2000 Feb 1;345 Pt 3:627-36.
REF 7 Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. J Transl Med. 2011 Jan 14;9:8.
REF 8 Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. J Biol Chem. 2010 Sep 3;285(36):27900-10.
REF 9 Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ER) and Biochemical Characterization of the ER-Hsp70 Interaction. PLoS One. 2016 Aug 2;11(8):e0160312.
REF 10 A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress Chaperones. 1996 Dec;1(4):237-50.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.