Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T98933 | Target Info | |||
Target Name | Thyroid hormone receptor beta (THRB) | ||||
Synonyms | c-erbA-beta; c-erbA-2; THR1; Nuclear receptor subfamily 1 group A member 2; NR1A2; ERBA2 | ||||
Target Type | Successful Target | ||||
Gene Name | THRB | ||||
Biochemical Class | Nuclear hormone receptor | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
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Acyltransferases | [+] 2 Acyltransferases | + | |||
Interacting Protein Name | Nuclear receptor coactivator 1 (NCOA1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Reconstituted Complex | [1] | |||
2 | Reconstituted Complex | [2] | |||
3 | Reconstituted Complex | [3] | |||
4 | Reconstituted Complex | [4] | |||
5 | Yeast two hybrid | [5] | |||
6 | Yeast two hybrid | [6] | |||
Interacting Target Name | Nuclear receptor coactivator 3 (NCOA3) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [7] | |||
2 | Reconstituted Complex | [8] | |||
3 | Yeast two hybrid | [6] | |||
Nuclear hormone receptors | [+] 1 Nuclear hormone receptors | + | |||
Interacting Target Name | Retinoic acid receptor RXR-alpha (RXRA) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1 | ||||
Evidence Score (E-score) | 7 Experimental Evidences | + | |||
1 | Co-localization | [9] | |||
2 | Far Western | [10] | |||
3 | Reconstituted Complex | [11] | |||
4 | Reconstituted Complex | [12] | |||
5 | Reconstituted Complex | [9] | |||
6 | Reconstituted Complex | [13] | |||
7 | Yeast two hybrid | [6] | |||
Transcription regulators | [+] 2 Transcription regulators | + | |||
Interacting Protein Name | Nuclear receptor corepressor 1 (NCOR1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [14] | |||
2 | Affinity Capture-Western | [15] | |||
3 | Far Western | [3] | |||
4 | Reconstituted Complex | [14] | |||
5 | Reconstituted Complex | [16] | |||
Interacting Protein Name | Nuclear receptor corepressor 2 (NCOR2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [14] | |||
2 | Far Western | [10] | |||
3 | Reconstituted Complex | [1] | |||
4 | Yeast two hybrid | [17] | |||
Other proteins | [+] 1 Other proteins | + | |||
Interacting Protein Name | Nuclear receptor coactivator 6 (NCOA6) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | AIB3; ASC2; NRC; PRIP; RAP250; TRBP | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Reconstituted Complex | [18] | |||
2 | Yeast two hybrid | [19] |
References | Top | ||||
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REF 1 | Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors. Endocrinology. 1998 Oct;139(10):4197-204. | ||||
REF 2 | Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. Mol Cell Biol. 1999 Sep;19(9):6323-32. | ||||
REF 3 | Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors. Mol Cell Biol. 1997 Apr;17(4):2166-76. | ||||
REF 4 | Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor. Mol Endocrinol. 1997 Jun;11(6):755-67. | ||||
REF 5 | A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. Nucleic Acids Res. 2013 Nov;41(21):9663-79. | ||||
REF 6 | Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13. | ||||
REF 7 | Thyroid hormone receptor 1 domains responsible for the antagonism with the ras oncogene: role of corepressors. Oncogene. 2011 Feb 17;30(7):854-64. | ||||
REF 8 | TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem. 1997 Oct 31;272(44):27629-34. | ||||
REF 9 | Regulation of AKR1B1 by thyroid hormone and its receptors. Mol Cell Endocrinol. 2009 Aug 13;307(1-2):109-17. | ||||
REF 10 | Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol Endocrinol. 1997 Dec;11(13):2025-37. | ||||
REF 11 | Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. J Biol Chem. 1997 Nov 21;272(47):29834-41. | ||||
REF 12 | Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene. Brain Res Mol Brain Res. 1998 Apr;55(2):321-30. | ||||
REF 13 | Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. J Biol Chem. 1997 May 30;272(22):14387-93. | ||||
REF 14 | Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity. J Biol Chem. 2007 Mar 30;282(13):9312-22. | ||||
REF 15 | Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation. J Biol Chem. 2015 Mar 20;290(12):7402-15. | ||||
REF 16 | Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature. 1995 Oct 5;377(6548):397-404. | ||||
REF 17 | Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance. Mol Endocrinol. 2001 Sep;15(9):1529-38. | ||||
REF 18 | Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Mol Endocrinol. 2002 Jan;16(1):128-40. | ||||
REF 19 | Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6212-7. |
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