| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T02777 | ||||
| Target Name | ATP-binding cassette transporter C9 (ABCC9) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Glimepiride | Drug Info | IC50 = 7.3 nM | [1] | |
| Repaglinide | Drug Info | Ki = 90 nMol/L | [2] | ||
| References | |||||
| REF 1 | Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels. Br J Pharmacol. 2001 May;133(1):193-9. | ||||
| REF 2 | Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels. Diabetologia. 2006 Sep;49(9):2039-48. | ||||
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