Target Validation Information
TTD ID	T09909
Target Name	Angiotensin II receptor type-2 (AGTR2)
Type of Target	Successful
Drug Potency against Target		Drug Info	IC50 = 20 nM
	ANGIOTENSIN II	Drug Info	IC50 = 2 nM
	Forasartan	Drug Info	IC50 = 6.9 nM
	L-158282	Drug Info	IC50 = 3 nM
	L-158809	Drug Info	IC50 = 37 nM
	L-159093	Drug Info	IC50 = 4500 nM	[6]
	L-159689	Drug Info	IC50 = 0.7 nM
	L-162234	Drug Info	IC50 = 0.45 nM	[1]
	L-162313	Drug Info	IC50 = 2 nM	[5]
	PD-123319	Drug Info	IC50 = 210 nM	[3]
	Sar-Arg-Val-Tyr-Ile-His-Pro-Ala	Drug Info	IC50 = 5.1 nM	[3]
	Sar-Arg-Val-Tyr-Ile-His-Pro-Ile	Drug Info	IC50 = 0.1 nM	[3]
	Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH	Drug Info	IC50 = 1.3 nM	[4]
	SARALASIN	Drug Info	Ki = 0.15 nM	[2]
	SC-50560	Drug Info	IC50 = 5.6 nM
	SC-51895	Drug Info	IC50 = 12 nM
	SC-52892	Drug Info	IC50 = 6.5 nM
	SC-55634	Drug Info	IC50 = 4.9 nM
References
REF 1	Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity. J Med Chem. 2000 May 18;43(10):1993-2006.
REF 2	cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
REF 3	Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 sub... J Med Chem. 1991 Nov;34(11):3248-60.
REF 4	1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists. J Med Chem. 1991 Apr;34(4):1514-7.
REF 5	Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition. Bioorg Med Chem. 2010 Jun 15;18(12):4570-90.
REF 6	A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor. J Med Chem. 1993 Oct 15;36(21):3207-10.

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