| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T51843 | ||||
| Target Name | Virus RNA-dependent RNA polymerase (Viru RdRP) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | Drug Info | IC50 = 140 nM | [2] | ||
| Action against Disease Model | Drug Info | T-705 showed IC50 values of less than 0.5 |?g/ml in virus yield assays in MDCK cells against all three influenza virus types (A, B, C) with no signs of cytotoxicity. | [1] | ||
| References | |||||
| REF 1 | In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob Agents Chemother. 2002 Apr;46(4):977-81. | ||||
| REF 2 | Mechanism of action of T-705 against influenza virus. Antimicrob Agents Chemother. 2005 Mar;49(3):981-6. | ||||
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