Target Validation Information
TTD ID	T90553
Target Name	Microtubule affinity regulating kinase 3 (MARK3)
Type of Target	Clinical trial
Drug Potency against Target		Drug Info	IC50 = 27 nM	[2]
Action against Disease Model		Drug Info	Abrogated DNA damage-induced G2 arrest, leading to mitotic entry and subsequent cell death.	[1]
References
REF 1	Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
REF 2	The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res. 2000 Apr 15;60(8):2108-12.

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