Target Information

Target General Information

Top

Target ID

T11754 (Former ID: TTDS00177)

Target Name

Fatty acid amide hydrolase (FAAH)

Synonyms

Oleamidehydrolase; Anandamide amidohydrolase

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Gene Name

NO-GeName

Target Type

Successful target

[1]

Disease

[+] 1 Target-related Diseases

Corneal disease [ICD-11: 9A76-9A78]

Function

Degradesbioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

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UniProt ID

NOUNIPROTAC

Drugs and Modes of Action

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Approved Drug(s)

[+] 2 Approved Drugs

Propofol

Drug Info

Approved

Anaesthesia

[2], [3]

Thiopental

Drug Info

Approved

Anaesthesia

[4], [5]

Clinical Trial Drug(s)

[+] 5 Clinical Trial Drugs

IW-6118

Drug Info

Phase 2

Inflammation

[6]

JNJ-42165279

Drug Info

Phase 2

Anxiety disorder

[7]

PF-04457845

Drug Info

Phase 2

Liver disease

[8]

SSR411298

Drug Info

Phase 2

Major depressive disorder

[9]

IPI-940

Drug Info

Phase 1

Pain

[10]

Mode of Action

[+] 2 Modes of Action

Inhibitor

[+] 253 Inhibitor drugs

Propofol

Drug Info

[1], [11]

Thiopental

Drug Info

[1]

JNJ-42165279

Drug Info

[13]

PF-04457845

Drug Info

[14]

SSR411298

Drug Info

[15]

IPI-940

Drug Info

[16]

Aryl urea derivative 1

Drug Info

[17]

Aryl urea derivative 2

Drug Info

[17]

Aryl urea derivative 3

Drug Info

[17]

Aryl urea derivative 5

Drug Info

[17]

Azetidine urea derivative 1

Drug Info

[17]

Azetidine urea derivative 2

Drug Info

[17]

Azetidine urea derivative 3

Drug Info

[17]

Azole derivative 1

Drug Info

[17]

Azole derivative 2

Drug Info

[17]

Azole derivative 3

Drug Info

[17]

Azole derivative 4

Drug Info

[17]

Azole derivative 5

Drug Info

[17]

Benzoxazole derivative 1

Drug Info

[17]

Benzyl pyrrolyloxoacetamide derivative 1

Drug Info

[17]

Benzyl pyrrolyloxoacetamide derivative 2

Drug Info

[17]

Boronic acid derivative 1

Drug Info

[17]

Boronic acid derivative 2

Drug Info

[17]

Boronic acid derivative 3

Drug Info

[17]

Boronic acid derivative 4

Drug Info

[17]

Boronic acid derivative 5

Drug Info

[17]

Boronic acid derivative 6

Drug Info

[17]

Carbamate derivative 1

Drug Info

[17]

Carbamate derivative 16

Drug Info

[18]

Carbamate derivative 17

Drug Info

[18]

Carbamate derivative 3

Drug Info

[17]

Carbamate derivative 8

Drug Info

[17]

Carbamate derivative 9

Drug Info

[18]

Carbamide derivative 1

Drug Info

[17]

Carbamide derivative 24

Drug Info

[18]

Carbamide derivative 25

Drug Info

[18]

Carbamide derivative 26

Drug Info

[18]

Enol carbamate derivative 1

Drug Info

[17]

Ethylaminopyrimidine derivative 1

Drug Info

[17]

Heteroaryl-substituted urea derivative 1

Drug Info

[17]

Heteroaryl-substituted urea derivative 2

Drug Info

[17]

Imidazolyl urea derivative 1

Drug Info

[17]

Isoxazoline derivative 1

Drug Info

[17]

Isoxazoline derivative 2

Drug Info

[17]

Isoxazoline derivative 4

Drug Info

[17]

Ketoheterocycle derivative 3

Drug Info

[17]

N-alkyl-4-oxazolecar boxamide derivative 1

Drug Info

[17]

N-alkyl-4-oxazolecar boxamide derivative 2

Drug Info

[17]

Piperazine carbamic compound 1

Drug Info

[18]

Piperazine carbamic compound 2

Drug Info

[18]

Piperazine urea derivative 1

Drug Info

[17]

PMID26413912-Compound-84

Drug Info

[17]

PMID29053063-Compound-11d

Drug Info

[18]

PMID29053063-Compound-15

Drug Info

[18]

Pyrazole derivative 81

Drug Info

[18]

Pyrazole derivative 82

Drug Info

[18]

Pyrazole derivative 83

Drug Info

[18]

Pyrimidinyl ethylenediamine derivative 1

Drug Info

[17]

Spirocyclic diamine urea derivative 1

Drug Info

[17]

Spirocyclic diamine urea derivative 2

Drug Info

[17]

Tetra-hydro-naphthalene derivative 1

Drug Info

[17]

Tetra-hydro-naphthalene derivative 3

Drug Info

[17]

Tetra-hydro-naphthyridine derivative 1

Drug Info

[17]

Tetra-substituted urea derivative 1

Drug Info

[17]

Tetra-substituted urea derivative 2

Drug Info

[17]

Tetrazolyl urea derivative 1

Drug Info

[17]

(+/-)-3-(but-3-enyl)-1-pent-4-enoylazetidin-2-one

Drug Info

[19]

(+/-)-3-allyl-1-pent-4-enoylazetidin-2-one

Drug Info

[19]

(+/-)-3-allylazetidin-2-one

Drug Info

[19]

(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate

Drug Info

[20]

(+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate

Drug Info

[20]

(Z)-1,1,1-Trifluoro-nonadec-10-en-2-one

Drug Info

[21]

(Z)-1-(4-phenyloxazol-2-yl)octadec-9-en-1-one

Drug Info

[22]

(Z)-1-(benzo[d]oxazol-2-yl)octadec-9-en-1-one

Drug Info

[22]

(Z)-1-(pyridazin-3-yl)octadec-9-en-1-one

Drug Info

[22]

(Z)-2,2-Dimethyl-1-oxazol-2-yl-octadec-9-en-1-one

Drug Info

[23]

(Z)-2-Methyl-1-oxazol-2-yl-octadec-9-en-1-one

Drug Info

[23]

1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one

Drug Info

[24]

1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one

Drug Info

[24]

1,1,1-trifluoro-3-(octylthio)propan-2-one

Drug Info

[24]

1,1,1-Trifluoro-7-phenylheptan-2-one

Drug Info

[21]

1,1,1-Trifluoro-8-phenyl-octan-2-one

Drug Info

[21]

1,1,1-Trifluoro-9-phenyl-nonan-2-one

Drug Info

[21]

1,1,1-Trifluoro-nonadecan-2-one

Drug Info

[21]

1,1,1-Trifluoro-tridecan-2-one

Drug Info

[21]

1,1,1-Trifluoro-undecan-2-one

Drug Info

[21]

1,1,1-trifluorododecan-2-one

Drug Info

[24]

1,10-(methylenedi-4,1-phenylene)bismaleimide

Drug Info

[25]

1,4-bis(malimido)xylene

Drug Info

[25]

1,8-bis-maleimidodiethyleneglycol

Drug Info

[25]

1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one

Drug Info

[26]

1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one

Drug Info

[26]

1-(1,3,4-oxadiazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

1-(1,3,4-thiadiazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

1-(4-acetyloxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

1-(4-bromooxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

1-(4-chlorooxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

1-(4-iodooxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

1-(4-methoxyoxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

100

1-(5-(furan-2-yl)oxazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

101

1-(5-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

102

1-(5-(pyridin-2-yl)oxazol-2-yl)octan-1-one

Drug Info

[22]

103

1-(5-(pyridin-2-yl)oxazol-2-yl)pentan-1-one

Drug Info

[22]

104

1-(5-fluorooxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[22]

105

1-(5-methyloxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[22]

106

1-(5-phenyloxazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

107

1-(5-Pyridin-2-yl-oxazol-2-yl)-octadec-9-yn-1-one

Drug Info

[21]

108

1-(oxazol-2-yl)-4-(piperidin-4-yl)butan-1-one

Drug Info

[28]

109

1-(oxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

110

1-(oxazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

111

1-(oxazolo[4,5-b]pyridin-2-yl)octan-1-one

Drug Info

[22]

112

1-(oxazolo[4,5-b]pyridin-2-yl)pentan-1-one

Drug Info

[22]

113

1-Benzooxazol-2-yl-6-phenyl-hexan-1-one

Drug Info

[21]

114

1-Biphenyl-4-ylmaleimide

Drug Info

[25]

115

1-Biphenyl-4-ylmethylmaleimide

Drug Info

[25]

116

1-DODECANOL

Drug Info

[29]

117

1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one

Drug Info

[30]

118

1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-yn-1-one

Drug Info

[21]

119

2,2-dimethyl-3-methyleneheptadecane

Drug Info

[24]

120

2,4-difluorophenyl 4-butoxybenzylcarbamate

Drug Info

[31]

121

2-(7-phenylheptanoyl)oxazole-4-carbaldehyde

Drug Info

[27]

122

2-(7-phenylheptanoyl)oxazole-4-carbonitrile

Drug Info

[27]

123

2-(7-phenylheptanoyl)oxazole-4-carboxamide

Drug Info

[27]

124

2-(7-phenylheptanoyl)oxazole-4-carboxylic acid

Drug Info

[27]

125

2-(7-phenylheptanoyl)oxazole-5-carboxylic acid

Drug Info

[27]

126

2-(biphenyl-4-yl)vinylboronic acid

Drug Info

[32]

127

2-arachidonoylglycerol

Drug Info

[33]

128

2-chloro-1-(5-(pyridin-2-yl)oxazol-2-yl)ethanone

Drug Info

[34]

129

2-Cyclohexylacetic acidbiphenyl-3-yl ester

Drug Info

[35]

130

2-fluorophenyl 4'-ethylbiphenyl-4-ylcarbamate

Drug Info

[31]

131

2-fluorophenyl 4-(decyloxy)phenylcarbamate

Drug Info

[31]

132

2-fluorophenyl 4-(dodecyloxy)phenylcarbamate

Drug Info

[31]

133

2-fluorophenyl 4-(heptyloxy)phenylcarbamate

Drug Info

[31]

134

2-fluorophenyl 4-(hexyloxy)phenylcarbamate

Drug Info

[31]

135

2-fluorophenyl 4-(octyloxy)phenylcarbamate

Drug Info

[31]

136

2-fluorophenyl 4-(undecyloxy)phenylcarbamate

Drug Info

[31]

137

2-fluorophenyl 4-butoxybenzylcarbamate

Drug Info

[31]

138

2-fluorophenyl 4-butoxyphenylcarbamate

Drug Info

[31]

139

2-methoxyphenylboronic acid

Drug Info

[32]

140

3'-carbamoylbiphenyl-3-yl 6-phenylhexylcarbamate

Drug Info

[36]

141

3,3-di(pent-4-enyl)azetidin-2-one

Drug Info

[19]

142

3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate

Drug Info

[37]

143

3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate

Drug Info

[37]

144

3-(biphenyl-4-yl)-1-(oxazol-2-yl)propan-1-one

Drug Info

[38]

145

3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one

Drug Info

[24]

146

3-(decylthio)-1,1,1-trifluoropropan-2-one

Drug Info

[24]

147

3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one

Drug Info

[24]

148

3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one

Drug Info

[24]

149

3-(ethoxycarbonyl)phenylboronic acid

Drug Info

[32]

150

3-(trifluoromethyl)phenyl 4-butoxybenzylcarbamate

Drug Info

[31]

151

3-(trifluoromethyl)phenylboronic acid

Drug Info

[32]

152

3-chlorophenyl 4-butoxybenzylcarbamate

Drug Info

[31]

153

3-cyanophenylboronic acid

Drug Info

[32]

154

4-(1,2,3-thiadiazol-4-yl)phenyl butylcarbamate

Drug Info

[39]

155

4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate

Drug Info

[39]

156

4-(cyclohexylmethylcarbamoyloxy)benzoic acid

Drug Info

[36]

157

4-(thiazol-2-yl)phenyl butylcarbamate

Drug Info

[40]

158

4-(trifluoromethyl)phenylboronic acid

Drug Info

[32]

159

4-cyanophenyl ethyl dodecylphosphonate

Drug Info

[41]

160

4-cyanophenylboronic acid

Drug Info

[32]

161

4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate

Drug Info

[31]

162

4-fluorophenylboronic acid

Drug Info

[32]

163

4-methoxyphenylboronic acid

Drug Info

[32]

164

4-Nitrophenyl 4-Benzylpiperazine-1-carboxylate

Drug Info

[42]

165

4-nitrophenylboronic acid

Drug Info

[32]

166

4-nonylphenylboronic acid

Drug Info

[32]

167

4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

168

6-fluoropyridin-3-ylboronic acid

Drug Info

[32]

169

6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

170

7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one

Drug Info

[26]

171

7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one

Drug Info

[26]

172

7-phenyl-1-(4-phenyloxazol-2-yl)heptan-1-one

Drug Info

[27]

173

7-phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one

Drug Info

[26]

174

7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one

Drug Info

[26]

175

7-Phenyl-1-(thiazol-2-yl)-heptan-1-one

Drug Info

[26]

176

8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

177

Allylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

178

AM-404

Drug Info

[43]

179

ARACHIDONYL TRIFLUOROMETHYLKETONE

Drug Info

[44]

180

Benzaldehyde O-4-(decyloxy)phenylcarbamoyl oxime

Drug Info

[31]

181

Benzaldehyde O-4-(heptyloxy)phenylcarbamoyl oxime

Drug Info

[31]

182

Benzaldehyde O-4-(hexyloxy)phenylcarbamoyl oxime

Drug Info

[31]

183

Benzaldehyde O-4-(nonyloxy)phenylcarbamoyl oxime

Drug Info

[31]

184

Benzaldehyde O-4-(octyloxy)phenylcarbamoyl oxime

Drug Info

[31]

185

Benzaldehyde O-4-(pentyloxy)phenylcarbamoyl oxime

Drug Info

[31]

186

Benzaldehyde O-4-butoxyphenylcarbamoyl oxime

Drug Info

[31]

187

Benzaldehyde O-4-ethoxyphenylcarbamoyl oxime

Drug Info

[31]

188

Benzaldehyde O-4-methoxyphenylcarbamoyl oxime

Drug Info

[31]

189

Benzofuran-2-ylboronic acid

Drug Info

[32]

190

Benzo[b]thiophen-2-ylboronic acid

Drug Info

[32]

191

Benzylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

192

Biphenyl-3-ylboronic acid

Drug Info

[32]

193

Biphenyl-4-ylboronic acid

Drug Info

[32]

194

BMS-1

Drug Info

[45]

195

bromoenol lactone

Drug Info

[36]

196

Cyclobutylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

197

Cyclohexyl biphenyl-4-ylcarbamate

Drug Info

[39]

198

Cyclohexylcarbamic acidbiphenyl-3-yl ester

Drug Info

[35]

199

Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

200

Cyclopentyl(5-(pyridin-2-yl)oxazol-2-yl)methanone

Drug Info

[34]

201

Cyclopentylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

202

Dodecane-1-sulfonyl fluoride

Drug Info

[41]

203

Ethyl octylfluorophosphonate

Drug Info

[46]

204

HTS-00798

Drug Info

[40]

205

Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

206

Isopropyl 4-nitrophenyl dodecylphosphonate

Drug Info

[41]

207

Isopropyl dodecylfluorophosphonate

Drug Info

[46]

208

Isopropylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

209

Methoxy arachidonyl fluorophosphonate

Drug Info

[47]

210

Methyl 2-(7-phenylheptanoyl)oxazole-4-carboxylate

Drug Info

[27]

211

Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate

Drug Info

[26]

212

Methyl icosylphosphonofluoridate

Drug Info

[41]

213

N-(2-hydroxyethyl)linoleoylamide

Drug Info

[48]

214

N-(2-iodethyl)arachidonylamide

Drug Info

[48]

215

N-(2-iodoethyl)linoleoylamide

Drug Info

[48]

216

N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide

Drug Info

[43]

217

N-arachidonylmaleimide

Drug Info

[25]

218

N-Butylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

219

N-Hexylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

220

Naphthalen-2-yl cyclohexylcarbamate

Drug Info

[36]

221

NICARBAZIN

Drug Info

[49]

222

Nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime

Drug Info

[31]

223

Nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime

Drug Info

[31]

224

Nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime

Drug Info

[31]

225

Octane-1-sulfonyl fluoride

Drug Info

[41]

226

OL-135

Drug Info

[50]

227

OL-92

Drug Info

[45]

228

Org-231295

Drug Info

[16], [44]

229

PARAOXON

Drug Info

[46]

230

PF3845

Drug Info

[51]

231

Phenethylboronic acid

Drug Info

[32]

232

Phenethylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

233

PHENMEDIPHAM

Drug Info

[49]

234

Phenyl 1-(4-butoxyphenyl)propylcarbamate

Drug Info

[31]

235

Phenyl 4-(dodecyloxy)phenylcarbamate

Drug Info

[31]

236

Phenyl 4-(heptyloxy)phenylcarbamate

Drug Info

[31]

237

Phenyl 4-(hexyloxy)phenylcarbamate

Drug Info

[31]

238

Phenyl 4-(octyloxy)phenylcarbamate

Drug Info

[31]

239

Phenyl 4-(undecyloxy)phenylcarbamate

Drug Info

[31]

240

Phenyl Boronic acid

Drug Info

[32]

241

Phenyl-1,4-bismaleimide

Drug Info

[25]

242

Phenylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[35]

243

Propan-2-one O-3-butoxyphenylcarbamoyl oxime

Drug Info

[31]

244

Propan-2-one O-4-(decyloxy)phenylcarbamoyl oxime

Drug Info

[31]

245

Propan-2-one O-4-(heptyloxy)phenylcarbamoyl oxime

Drug Info

[31]

246

Propan-2-one O-4-(hexyloxy)phenylcarbamoyl oxime

Drug Info

[31]

247

Propan-2-one O-4-(nonyloxy)phenylcarbamoyl oxime

Drug Info

[31]

248

Propan-2-one O-4-(octyloxy)phenylcarbamoyl oxime

Drug Info

[31]

249

Propan-2-one O-4-butoxybenzylcarbamoyl oxime

Drug Info

[31]

250

Propan-2-one O-4-butoxyphenylcarbamoyl oxime

Drug Info

[31]

251

Propan-2-one O-4-propoxyphenylcarbamoyl oxime

Drug Info

[31]

252

Pyridin-3-yl 4-butoxybenzylcarbamate

Drug Info

[31]

253

VER-156084

Drug Info

[52]

Modulator

[+] 1 Modulator drugs

IW-6118

Drug Info

[12]

Drug Property Profile of Target

Top

(1) Molecular Weight (mw) based Drug Clustering

(2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering

(3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering

(4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering

(5) Rotatable Bond Count (rotbonds) based Drug Clustering

(6) Topological Polar Surface Area (polararea) based Drug Clustering

"RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five

Co-Targets

Top

Co-Targets

Co-Targets Info

Target Profiles in Patients

Top

Target Expression
Profile (TEP)

Target Expression Profile Info

Target Affiliated Biological Pathways

Top

BioCyc

[+] 1 BioCyc Pathways

Anandamide degradation

KEGG Pathway

[+] 1 KEGG Pathways

Retrograde endocannabinoid signaling

Panther Pathway

[+] 1 Panther Pathways

Anandamide degradation

Target-Related Models and Studies

Top

Target Validation

Target Validation Info

References

Top

REF 1

The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13.

REF 2

URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5464).

REF 3

Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000 Feb;7(2):249-71.

REF 4

REF 5

FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011679.

REF 6

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