Target Information
| Target General Information | Top | |||||
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| Target ID |
T57750
(Former ID: TTDR00024)
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| Target Name |
Staphylococcus DHNA-CoA synthase (Stap-coc menB)
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| Synonyms |
DHNA-CoA synthase; 1,4-dihydroxy-2-naphthoyl-CoA synthase
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| Gene Name |
Stap-coc menB
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
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| BioChemical Class |
Carbon-carbon lyase
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| UniProt ID | ||||||
| Sequence |
MTNRQWETLREYDEIKYEFYEGIAKVTINRPEVRNAFTPKTVAEMIDAFSRARDDQNVSV
IVLTGEGDLAFCSGGDQKKRGHGGYVGEDQIPRLNVLDLQRLIRIIPKPVIAMVKGYAVG GGNVLNVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARIVGHKKAREIWYLCRQYNA QEALDMGLVNTVVPLEKVEDETVQWCKEIMKHSPTALRFLKAAMNADTDGLAGLQQMAGD ATLLYYTTDEAKEGRDAFKEKRDPDFDQFPKFP Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Acetoacetyl-Coenzyme A | Ligand Info | |||||
| Structure Description | Crystal structure of Staphylococcus aureus 1,4-dihydroxy-2-naphthoyl CoA synthase (MenB) in complex with acetoacetyl CoA | PDB:2UZF | ||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [2] |
| PDB Sequence |
WETLREYDEI
15 KYEFYEGIAK25 VTINRPEVRN35 AFTPKTVAEM45 IDAFSRARDD55 QNVSVIVLTG 65 EGDLAFCSGG75 DQKGEDQIPR93 LNVLDLQRLI103 RIIPKPVIAM113 VKGYAVGGGN 123 VLNVVCDLTI133 AADNAIFGQT143 GPKVGSFDAG153 YGSGYLARIV163 GHKKAREIWY 173 LCRQYNAQEA183 LDMGLVNTVV193 PLEKVEDETV203 QWCKEIMKHS213 PTALRFLKAA 223 MNADTDGLAG233 LQQMAGDATL243 LYYTTDEAKE253 GRDAFKEKRD263 PDFDQFPKFP 273
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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| Protein Name | Pfam ID | Percentage of Identity (%) | E value |
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| 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH) | 25.532 (36/141) | 6.20E-10 |
| References | Top | |||||
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| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||||
| REF 2 | Structure of Staphylococcus aureus1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Nov 1;63(Pt 11):908-13. | |||||
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