Target Information

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Target General Information
Drugs and Modes of Action
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
Drug Property Profile of Target
Target Poor or Non Binders
Target Affiliated Biological Pathways
Target-Related Models and Studies
References
Drug Binding Sites of Target  Top
Ligand Name: N-[(2S)-1-[[(Z,3S)-1-(benzenesulfonyl)hex-1-en-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]-4-morpholin-4-ylpiperidine-1-carboxamide Ligand Info
Structure Description Crystal structure of human cathepsin F PDB:1M6D
Method X-ray diffraction Resolution 1.70 Å Mutation Yes [5]
PDB Sequence
APPEWDWRSK
10
GAVTKVKDQG
20
MCGSCWAFSV
30
TGNVEGQWFL
40
NQGTLLSLSE
50

QELLDCDKMD
60
KACMGGLPSN
70
AYSAIKNLGG
79
LETEDDYSYQ
89
GHMQSCQFSA
99

EKAKVYIQDS
110
VELSQNEQKL
120
AAWLAKRGPI
130
SVAINAFGMQ
142
FYRHGISRPL
154A

RPLCSPWLID
158
HAVLLVGYGQ
167A
RSDVPFWAIK
174
NSWGTDWGEK
184
GYYYLHRGSG
198

ACGVNTMASS
208
AVVD
Residue
Distance (Å)
GLN19
3.004
CYS22
4.066
GLY23
3.420
SER24
4.582
CYS25
1.824
TRP26
3.209
CYS63
4.157
MET64
3.741
GLY65
3.099
GLY66
2.893
LEU67
3.537
Residue
Distance (Å)
PRO68
4.137
ALA133
3.839
ALA136
4.100
GLN142
3.246
ILE157
3.554
ASP158
3.048
HIS159
3.231
ALA160
4.561
TRP177
2.868
MET205
3.789
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
 Download Picture         KEGG Link      
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Lysosome hsa04142 Affiliated Target
  Class: Cellular Processes => Transport and catabolism Pathway Hierarchy
Apoptosis hsa04210 Affiliated Target
  Class: Cellular Processes => Cell growth and death Pathway Hierarchy

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