Target Information

Target General Information

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Target ID

T89752 (Former ID: TTDI03563)

Target Name

Sugen kinase 110 (SBK3)

Synonyms

Uncharacterized serine/threonine-protein kinase SBK3; SH3-binding domain kinase family member 3; SGK110

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Gene Name

SBK3

Target Type

Literature-reported target

[1]

Function

A serine/threonine protein kinase that does not have an activating compound and are either non-specific or their specificity has not been analyzed to date.

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UniProt ID

SBK3_HUMAN

EC Number

EC 2.7.11.1

Sequence

MERRASETPEDGDPEEDTATALQRLVELTTSRVTPVRSLRDQYHLIRKLGSGSYGRVLLA
QPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCVSAHPGLLQTLAGPLQTPRYFAFAQEY
APCGDLSGMLQERGLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVFDPVCSRVA
LGDLGLTRPEGSPTPAPPVPLPTAPPELCLLLPPDTLPLRPAVDSWGLGVLLFCAATACF
PWDVALAPNPEFEAFAGWVTTKPQPPQPPPPWDQFAPPALALLQGLLDLDPETRSPPLAV
LDFLGDDWGLQGNREGPGVLGSAVSYEDREEGGSSLEEWTDEGDDSKSGGRTGTDGGAP

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3D Structure

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AlphaFold

Cell-based Target Expression Variations

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Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

Protein Name	Pfam ID	Percentage of Identity (%)	E value
Tyrosine-protein kinase ABL2 (ABL2)	PF08919 ; PF07714 ; PF00017 ; PF00018 More >>	28.780 (59/205)	6.94E-14
LCK tyrosine protein kinase (LCK)	PF07714 ; PF00017 ; PF00018 More >>	26.500 (53/200)	1.29E-11
LIM domain kinase-1 (LIMK-1)	PF00412 ; PF00595 ; PF07714 More >>	30.070 (43/143)	1.84E-11
B lymphocyte kinase (BLK)	PF07714 ; PF00017 ; PF00018 More >>	27.451 (56/204)	3.45E-11
Focal adhesion kinase 1 (FAK)	PF00373 ; PF18038 ; PF03623 ; PF07714 More >>	28.155 (58/206)	4.16E-10
Fyn tyrosine protein kinase (FYN)	PF07714 ; PF00017 ; PF00018 More >>	25.688 (56/218)	5.12E-10
Tyrosine-protein kinase CSK (CSK)	PF07714 ; PF00017 ; PF00018 More >>	26.563 (51/192)	9.00E-10
Tyrosine-protein kinase FRK (FRK)	PF07714 ; PF00017 ; PF00018 More >>	30.000 (63/210)	1.38E-09
Tyrosine-protein kinase Fgr (FGR)	PF07714 ; PF00017 ; PF00018 More >>	27.723 (56/202)	3.21E-09
Tyrosine-protein kinase Lyn (JTK8)	PF07714 ; PF00017 ; PF00018 More >>	23.810 (50/210)	4.01E-09
Focal adhesion kinase 2 (PTK2B)	PF00373 ; PF18038 ; PF03623 ; PF07714 More >>	31.210 (49/157)	4.83E-09
Hematopoietic cell kinase (HCK)	PF07714 ; PF00017 ; PF00018 More >>	25.604 (53/207)	8.99E-09
Megakaryocyte-associated tyrosine-protein kinase (MATK)	PF07714 ; PF00017 ; PF00018 More >>	26.455 (50/189)	1.17E-08
Proto-oncogene c-Src (SRC)	PF07714 ; PF00017 ; PF00018 More >>	28.713 (58/202)	1.25E-08
Mixed lineage kinase 3 (MAP3K11)	PF07714 ; PF14604	27.329 (44/161)	6.63E-08
BDNF/NT-3 growth factors receptor (TrkB)	PF07679 ; PF13855 ; PF16920 ; PF01462 ; PF07714 More >>	26.423 (65/246)	7.84E-08
Proto-oncogene c-RAF (c-RAF)	PF00130 ; PF07714 ; PF02196 More >>	23.762 (48/202)	9.01E-08
Serine/threonine-protein kinase A-Raf (ARAF)	PF00130 ; PF07714 ; PF02196 More >>	23.077 (48/208)	1.35E-07
LIM domain kinase-2 (LIMK-2)	PF00412 ; PF00595 ; PF07714 More >>	28.169 (40/142)	1.43E-07
Serine/threonine-protein kinase LMTK1 (AATK)	PF07714	27.044 (43/159)	1.59E-07
Tyrosine-protein kinase BMX (BMX)	PF00779 ; PF00169 ; PF07714 ; PF00017 More >>	24.000 (48/200)	2.29E-07
Yes tyrosine kinase (YES)	PF07714 ; PF00017 ; PF00018 More >>	25.373 (51/201)	2.80E-07
Fibroblast growth factor receptor 2 (FGFR2)	PF07679 ; PF13927 ; PF07714 More >>	24.444 (55/225)	2.81E-07
Fibroblast growth factor receptor 1 (FGFR1)	PF07679 ; PF00047 ; PF07714 More >>	26.222 (59/225)	3.23E-07
TYK2 tyrosine kinase (TYK2)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	27.434 (62/226)	4.89E-07
Ephrin type-A receptor 1 (EPHA1)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	25.980 (53/204)	6.80E-07
Ephrin type-A receptor 3 (EPHA3)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF07647 More >>	23.301 (48/206)	6.87E-07
Serine/threonine-protein kinase LMTK3 (LMTK3)	PF07714	28.000 (49/175)	8.32E-07
Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)	PF07714	25.628 (51/199)	9.73E-07
Receptor-interacting protein 1 (RIPK1)	PF00531 ; PF07714 ; PF12721 More >>	25.352 (36/142)	1.07E-06
Tie-1 tyrosine kinase receptor (TIE1)	PF00041 ; PF00047 ; PF07714 More >>	25.728 (53/206)	1.81E-06
Mitogen-activated protein kinase kinase kinase 12 (MAP3K12)	PF07714	26.000 (52/200)	2.06E-06
Tyrosine-protein kinase BRK (PTK6)	PF07714 ; PF00017 ; PF00018 More >>	26.500 (53/200)	2.57E-06
Ephrin type-A receptor 8 (EPHA8)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	25.238 (53/210)	3.37E-06
Mixed lineage kinase 2 (MAP3K10)	PF07714 ; PF14604	25.463 (55/216)	4.33E-06
Non-receptor tyrosine-protein kinase TNK1 (TNK1)	PF07714	32.692 (68/208)	8.02E-06
ALK tyrosine kinase receptor (ALK)	PF12810 ; PF00629 ; PF07714 More >>	24.893 (58/233)	9.79E-06
Ephrin type-A receptor 7 (EPHA7)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	24.638 (51/207)	1.04E-05
Serine/threonine-protein kinase LMTK2 (LMTK2)	PF07714	25.294 (43/170)	1.06E-05
Ephrin type-A receptor 5 (EPHA5)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	24.155 (50/207)	1.07E-05
Bone morphogenetic protein receptor type-1A (BMPR1A)	PF01064 ; PF07714 ; PF08515 More >>	21.284 (63/296)	1.07E-05
Activated CDC42 kinase 1 (ACK-1)	PF09027 ; PF11555 ; PF07714 ; PF14604 More >>	30.065 (46/153)	1.09E-05
Testis-specific kinase 2 (TESK2)	PF07714	26.241 (37/141)	1.32E-05
NT-3 growth factor receptor (TrkC)	PF07679 ; PF00047 ; PF13855 ; PF16920 ; PF01462 ; PF07714 More >>	25.210 (60/238)	1.72E-05
Neurotrophic tyrosine kinase ROR2 (ROR2)	PF01392 ; PF07679 ; PF00051 ; PF07714 More >>	27.381 (46/168)	2.14E-05
Fibroblast growth factor receptor 3 (FGFR3)	PF07679 ; PF13927 ; PF07714 More >>	24.889 (56/225)	2.16E-05
TYRO3 tyrosine kinase receptor (TYRO3)	PF00041 ; PF07679 ; PF07714 More >>	27.545 (46/167)	2.97E-05
Tyrosine-protein kinase STYK1 (STYK1)	PF07714	24.790 (59/238)	4.14E-05
Janus kinase 3 (JAK-3)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	25.957 (61/235)	4.88E-05
Testis-specific kinase 1 (TESK1)	PF07714	28.889 (39/135)	6.61E-05
Janus kinase 2 (JAK-2)	PF18379 ; PF18377 ; PF17887 ; PF07714 ; PF00017 More >>	25.962 (54/208)	7.36E-05
Ephrin type-B receptor 1 (EPHB1)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	23.267 (47/202)	7.57E-05
Dual serine/threonine and tyrosine protein kinase (DSTYK)	PF07714	28.155 (29/103)	1.07E-04
Serine/threonine-protein kinase B-raf (BRAF)	PF00130 ; PF07714 ; PF02196 More >>	23.786 (49/206)	1.94E-04
Muscle-specific kinase receptor (MUSK)	PF01392 ; PF07679 ; PF13927 ; PF07714 More >>	22.650 (53/234)	2.24E-04
Bone morphogenetic protein receptor type-1B (BMPR1B)	PF01064 ; PF07714 ; PF08515 More >>	21.429 (57/266)	2.40E-04
Discoidin domain-containing receptor 2 (DDR2)	PF00754 ; PF07714	25.664 (58/226)	2.47E-04
Ephrin type-A receptor 2 (EPHA2)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	24.757 (51/206)	3.21E-04
Tropomyosin-related kinase A (TrkA)	PF13855 ; PF16920 ; PF07714 ; PF18613 More >>	26.577 (59/222)	5.25E-04
Ephrin type-B receptor 4 (EPHB4)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	23.529 (48/204)	5.56E-04
Kinase suppressor of Ras-1 (KSR1)	PF07714 ; PF13543 ; PF20406 More >>	22.381 (47/210)	5.74E-04
Insulin receptor-related protein (INSRR)	PF00757 ; PF07714 ; PF01030 More >>	27.545 (46/167)	5.88E-04
Ephrin type-B receptor 2 (EPHB2)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	22.772 (46/202)	7.23E-04
Ephrin type-B receptor 3 (EPHB3)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	22.705 (47/207)	7.62E-04
Fibroblast growth factor receptor 4 (FGFR4)	PF07679 ; PF13927 ; PF07714 More >>	24.859 (44/177)	1.00E-03
Ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1)	PF12796 ; PF13637 ; PF07714 More >>	23.158 (44/190)	1.00E-03
Kinase suppressor of Ras 2 (KSR2)	PF07714 ; PF13543 ; PF20406 More >>	23.500 (47/200)	3.00E-03
Tyrosine-protein kinase Srms (SRMS)	PF07714 ; PF00017	25.616 (52/203)	3.00E-03
Angiopoietin 1 receptor (TEK)	PF00041 ; PF10430 ; PF07714 More >>	24.405 (41/168)	4.00E-03
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References

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REF 1

Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group. Bioorg Med Chem. 2011 Nov 1;19(21):6274-84.

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