Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T90695
|
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| Target Name |
PI3K/AKT/mTOR pathway (PAm pathway)
|
|||||
| Gene Name |
NO-GeName
|
|||||
| Target Type |
Successful target
|
[1] | ||||
| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Multiple myeloma [ICD-11: 2A83] | |||||
| 2 | Transplant rejection [ICD-11: NE84] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Approved Drug(s) | [+] 1 Approved Drugs | + | ||||
| 1 | Sirolimus | Drug Info | Approved | Organ transplant rejection | [2], [3] | |
| Clinical Trial Drug(s) | [+] 1 Clinical Trial Drugs | + | ||||
| 1 | ON-01210.Na | Drug Info | Phase 1 | Radiation syndrome | [4] | |
| Discontinued Drug(s) | [+] 1 Discontinued Drugs | + | ||||
| 1 | Glypromate | Drug Info | Discontinued in Phase 2 | Neurological disorder | [5] | |
| Mode of Action | [+] 2 Modes of Action | + | ||||
| Inhibitor | [+] 2 Inhibitor drugs | + | ||||
| 1 | Sirolimus | Drug Info | [1], [6], [7] | |||
| 2 | ON-01210.Na | Drug Info | [8] | |||
| Modulator | [+] 1 Modulator drugs | + | ||||
| 1 | Glypromate | Drug Info | [9] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | The genomic landscape of nasopharyngeal carcinoma.Nat Genet. 2014 Aug;46(8):866-71. | |||||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6031). | |||||
| REF 3 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020974) | |||||
| REF 5 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021881) | |||||
| REF 6 | An orthotopic model of metastatic nasopharyngeal carcinoma and its application in elucidating a therapeutic target that inhibits metastasis.Genes Cancer. 2011 Nov;2(11):1023-33. | |||||
| REF 7 | Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma.Cancer Res. 2004 Aug 1;64(15):5251-60. | |||||
| REF 8 | ON01210.Na (Ex-RAD ) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355. | |||||
| REF 9 | Dendritic spine dysgenesis in Rett syndrome. Front Neuroanat. 2014; 8: 97. | |||||
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