Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Co-Targets
Target Affiliated Biological Pathways
References
Drug Binding Sites of Target  Top
Ligand Name: 1,3-Benzothiazol-2-ylmethylamine Ligand Info
Structure Description Ube2T in complex with fragment EM04 PDB:5NGZ
Method X-ray diffraction Resolution 2.40 Å Mutation No [4]
PDB Sequence
QRASRLKREL
11
HMLATEPPPG
21
ITCWQDKDQM
31
DDLRAQILGG
41
ANTPYEKGVF
51

KLEVIIPERY
61
PFEPPQIRFL
71
TPIYHPNIDS
81
AGRICLDVLK
91
LPPKGAWRPS
101

LNIATVLTSI
111
QLLMSEPNPD
121
DPLMADISSE
131
FKYNKPAFLK
141
NARQWTEKHA
151

RQ
Residue
Distance (Å)
PHE70
2.974
LEU71
3.419
THR72
3.748
PRO73
3.434
ILE74
3.438
ILE79
4.649
Residue
Distance (Å)
ASP80
3.294
SER81
2.992
ALA82
3.931
GLY83
3.727
TRP146
3.200
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Pathway Affiliation
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Fanconi anemia pathway hsa03460 Affiliated Target
  Class: Genetic Information Processing => Replication and repair Pathway Hierarchy
Degree 17 Degree centrality 1.83E-03 Betweenness centrality 6.67E-05
Closeness centrality 2.08E-01 Radiality 1.36E+01 Clustering coefficient 6.32E-01
Neighborhood connectivity 3.05E+01 Topological coefficient 1.49E-01 Eccentricity 12
Download Click to Download the Full PPI Network of This Target

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