Target General Information
Target ID T17234
Target Name HCMV Serine/threonine protein kinase (UL97)
Gene Name UL97
Species Human cytomegalovirus
UniProt ID UL97_HCMVA
Sequence MSSALRSRARSASLGTTTQGWDPPPLRRPSRARRRQWMREAAQAAAQAAVQAAQAAAAQV
AQAHVDENEVVDLMADEAGGGVTTLTTLSSVSTTTVLGHATFSACVRSDVMRDGEKEDAA
SDKENLRRPVVPSTSSRGSAASGDGYHGLRCRETSAMWSFEYDRDGDVTSVRRALFTGGS
DPSDSVSGVRGGRKRPLRPPLVSLARTPLCRRRVGGVDAVLEENDVELRAESQDSAVASG
PGRIPQPLSGSSGEESATAVEADSTSHDDVHCTCSNDQIITTSIRGLTCDPRMFLRLTHP
ELCELSISYLLVYVPKEDDFCHKICYAVDMSDESYRLGQGSFGEVWPLDRYRVVKVARKH
SETVLTVWMSGLIRTRAAGEQQQPPSLVGTGVHRGLLTATGCCLLHNVTVHRRFHTDMFH
HDQWKLACIDSYRRAFCTLADAIKFLNHQCRVCHFDITPMNVLIDVNPHNPSEIVRAALC
DYSLSEPYPDYNERCVAVFQETGTARRIPNCSHRLRECYHPAFRPMPLQKLLICDPHARF
PVAGLRRYCMSELSALGNVLGFCLMRLLDRRGLDEVRMGTEALLFKHAGAACRALENGKL
THCSDACLLILAAQMSYGACLLGEHGAALVSHTLRFVEAKMSSCRVRAFRRFYHECSQTM
LHEYVRKNVERLLATSDGLYLYNAFRRTTSIICEEDLDGDCRQLFPE [Human cytom
egalovirus]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: A594
Drugs
Drug Name Ganciclovir Drug Info [1]
Targeted Disease Bacterial infection
Mutation Info Missense: A594V
Drugs
Drug Name Ganciclovir Drug Info [1]
Targeted Disease Bacterial infection
Mutation Prevalence 26.43% of the specimens
Mutation Info Missense: C518Y
Drugs
Drug Name Ganciclovir Drug Info [3]
Targeted Disease Bacterial infection
Mutation Info Missense: C592G
Drugs
Drug Name Ganciclovir Drug Info [1]
Targeted Disease Bacterial infection
Mutation Prevalence 10.34% of the specimens
Mutation Info Missense: C603W
Drugs
Drug Name Ganciclovir Drug Info [1]
Targeted Disease Bacterial infection
Mutation Prevalence 6.89% of the specimens
Mutation Info Missense: C607F
Drugs
Drug Name Ganciclovir Drug Info [3]
Targeted Disease Bacterial infection
Mutation Info Missense: D605E
Drugs
Drug Name Ganciclovir Drug Info [3]
Targeted Disease Bacterial infection
Mutation Prevalence 30 out of 70
Mutation Info Missense: E596G
Drugs
Drug Name Ganciclovir Drug Info [1]
Targeted Disease Bacterial infection
Mutation Prevalence 1.14% of the specimens
Mutation Info Missense: H520Q
Drugs
Drug Name Ganciclovir Drug Info [1]
Targeted Disease Bacterial infection
Mutation Prevalence 18.39% of the specimens
Mutation Info Missense: L595S
Drugs
Drug Name Ganciclovir Drug Info [1]
Targeted Disease Bacterial infection
Mutation Prevalence 2.29% of the specimens
Mutation Info Missense: L595W
Drugs
Drug Name Ganciclovir Drug Info [3]
Targeted Disease Bacterial infection
Mutation Info Missense: M460I
Drugs
Drug Name Ganciclovir Drug Info [1]
Targeted Disease Bacterial infection
Mutation Prevalence 9.19% of the specimens
Mutation Info Missense: M460V
Drugs
Drug Name Ganciclovir Drug Info [1], [2]
Targeted Disease Bacterial infection
Mutation Prevalence 3.3% of patients
References
REF 1 Assessment of the Human Cytomegalovirus UL97 Gene for Identification of Resistance to Ganciclovir in Iranian Immunosuppressed Patients. Jundishapur J Microbiol. 2016 May 29;9(5):e31733.
REF 2 [Investigation of ganciclovir resistance in CMV UL54 and UL97 gene regions in immunocompromised patients receiving gancyclovir treatment].Mikrobiyol Bul.2015 Jul;49(3):393-402.
REF 3 A new mutation in the human cytomegalovirus UL97 gene may confer ganciclovir resistance in Chinese kidney transplant recipients.Arch Virol.2013 Jan;158(1):247-50.

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