Target General Information |
Target ID |
T17234
|
Target Name |
HCMV Serine/threonine protein kinase (UL97) |
Gene Name |
UL97 |
Species |
Human cytomegalovirus |
UniProt ID |
UL97_HCMVA |
Sequence |
MSSALRSRARSASLGTTTQGWDPPPLRRPSRARRRQWMREAAQAAAQAAVQAAQAAAAQV AQAHVDENEVVDLMADEAGGGVTTLTTLSSVSTTTVLGHATFSACVRSDVMRDGEKEDAA SDKENLRRPVVPSTSSRGSAASGDGYHGLRCRETSAMWSFEYDRDGDVTSVRRALFTGGS DPSDSVSGVRGGRKRPLRPPLVSLARTPLCRRRVGGVDAVLEENDVELRAESQDSAVASG PGRIPQPLSGSSGEESATAVEADSTSHDDVHCTCSNDQIITTSIRGLTCDPRMFLRLTHP ELCELSISYLLVYVPKEDDFCHKICYAVDMSDESYRLGQGSFGEVWPLDRYRVVKVARKH SETVLTVWMSGLIRTRAAGEQQQPPSLVGTGVHRGLLTATGCCLLHNVTVHRRFHTDMFH HDQWKLACIDSYRRAFCTLADAIKFLNHQCRVCHFDITPMNVLIDVNPHNPSEIVRAALC DYSLSEPYPDYNERCVAVFQETGTARRIPNCSHRLRECYHPAFRPMPLQKLLICDPHARF PVAGLRRYCMSELSALGNVLGFCLMRLLDRRGLDEVRMGTEALLFKHAGAACRALENGKL THCSDACLLILAAQMSYGACLLGEHGAALVSHTLRFVEAKMSSCRVRAFRRFYHECSQTM LHEYVRKNVERLLATSDGLYLYNAFRRTTSIICEEDLDGDCRQLFPE [Human cytom egalovirus]
|
Drug and Corresponding Resistance Mutations |
Mutation Info |
Missense: A594 |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[1] |
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: A594V |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[1] |
Targeted Disease |
Bacterial infection |
Mutation Prevalence |
26.43% of the specimens |
|
Mutation Info |
Missense: C518Y |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[3] |
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: C592G |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[1] |
Targeted Disease |
Bacterial infection |
Mutation Prevalence |
10.34% of the specimens |
|
Mutation Info |
Missense: C603W |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[1] |
Targeted Disease |
Bacterial infection |
Mutation Prevalence |
6.89% of the specimens |
|
Mutation Info |
Missense: C607F |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[3] |
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: D605E |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[3] |
Targeted Disease |
Bacterial infection |
Mutation Prevalence |
30 out of 70 |
|
Mutation Info |
Missense: E596G |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[1] |
Targeted Disease |
Bacterial infection |
Mutation Prevalence |
1.14% of the specimens |
|
Mutation Info |
Missense: H520Q |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[1] |
Targeted Disease |
Bacterial infection |
Mutation Prevalence |
18.39% of the specimens |
|
Mutation Info |
Missense: L595S |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[1] |
Targeted Disease |
Bacterial infection |
Mutation Prevalence |
2.29% of the specimens |
|
Mutation Info |
Missense: L595W |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[3] |
Targeted Disease |
Bacterial infection |
|
Mutation Info |
Missense: M460I |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[1] |
Targeted Disease |
Bacterial infection |
Mutation Prevalence |
9.19% of the specimens |
|
Mutation Info |
Missense: M460V |
Drugs |
Drug Name |
Ganciclovir |
Drug Info
|
[1], [2] |
Targeted Disease |
Bacterial infection |
Mutation Prevalence |
3.3% of patients |
|
References |
REF 1 |
Assessment of the Human Cytomegalovirus UL97 Gene for Identification of Resistance to Ganciclovir in Iranian Immunosuppressed Patients. Jundishapur J Microbiol. 2016 May 29;9(5):e31733.
|
REF 2 |
[Investigation of ganciclovir resistance in CMV UL54 and UL97 gene regions in immunocompromised patients receiving gancyclovir treatment].Mikrobiyol Bul.2015 Jul;49(3):393-402.
|
REF 3 |
A new mutation in the human cytomegalovirus UL97 gene may confer ganciclovir resistance in Chinese kidney transplant recipients.Arch Virol.2013 Jan;158(1):247-50.
|