Resistance mutation info of target
Target General Information | ||||||||||||||||||
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Target ID | T17345 | |||||||||||||||||
Target Name | Bacterial Dihydrofolate reductase (DHFR) | |||||||||||||||||
Gene Name | DHFR | |||||||||||||||||
Species | Streptococcus pneumoniae | |||||||||||||||||
UniProt ID | DYR_STRPN | |||||||||||||||||
Sequence |
MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPK RETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTH IHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV [Streptococ cus pneumoniae] |
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Drug and Corresponding Resistance Mutations | ||||||||||||||||||
Mutation Info | Missense: V100L | |||||||||||||||||
Drugs |
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References | ||||||||||||||||||
REF 1 | Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae. Biochemistry. 2010 Jan 12;49(1):195-206. |
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