Target General Information
Target ID T17345
Target Name Bacterial Dihydrofolate reductase (DHFR)
Gene Name DHFR
Species Streptococcus pneumoniae
UniProt ID DYR_STRPN
Sequence MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPK
RETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTH
IHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV [Streptococ
cus pneumoniae]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: V100L
Drugs
Drug Name Trimethoprim Drug Info [1]
Targeted Disease Bacterial infection
References
REF 1 Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae. Biochemistry. 2010 Jan 12;49(1):195-206.

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