Target General Information
Target ID T24634
Target Name Bacterial Enoylpyruvate transferase (murA)
Gene Name murA
Species Escherichia coli
UniProt ID MURA_ECOLI
Sequence MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL
GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR
PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT
IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV
AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP
AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL
SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
[Escherichia coli]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: D369N
Drugs
Drug Name Fosfomycin Drug Info [1]
Targeted Disease Bacterial infection
Mutation Info Missense: L370I
Drugs
Drug Name Fosfomycin Drug Info [1]
Targeted Disease Bacterial infection
References
REF 1 CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.

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