Target General Information
Target ID T35486
Target Name GTPase Nras (NRAS)
Gene Name NRAS
Species Homo sapiens
UniProt ID RASN_HUMAN
Sequence MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM [Homo sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: G12D
Drugs
Drug Name Dabrafenib Drug Info [2]
Targeted Disease Melanoma
Mutation Prevalence 1 out of 10 patients
Mutation Info Missense: Q61H
Drugs
Drug Name Vemurafenib Drug Info [1]
Mutation Prevalence 1 out of 76 patients
Mutation Info Missense: Q61K
Drugs
Drug Name Dabrafenib Drug Info [1]
Targeted Disease Melanoma
Mutation Prevalence 4 out of 76 patients
Drug Name Vemurafenib Drug Info [1], [4], [5]
Mutation Prevalence 4 out of 76 patients
Mutation Info Missense: Q61R
Drugs
Drug Name Pembrolizumab Drug Info [3]
Targeted Disease Melanoma
Mutation Prevalence 2 out of 49 patients
Drug Name Vemurafenib Drug Info [4], [1]
Mutation Prevalence 3 out of 76 patients
References
REF 1 The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Cancer Discov. 2014 Jan;4(1):94-109.
REF 2 Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma. Nat Commun. 2014 Dec 2;5:5694.
REF 3 Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma. Oncotarget. 2015 Dec 8;6(39):42008-18.
REF 4 Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature. 2010 Dec 16;468(7326):973-7.
REF 5 Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms. Am J Cancer Res. 2015 Mar 15;5(4):1507-18.

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