Target General Information
Target ID T40016
Target Name Glucocorticoid receptor (NR3C1)
Gene Name NR3C1
Species Homo sapiens
UniProt ID GCR_HUMAN
Sequence MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK [H
omo sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: L672P
Drugs
Drug Name Generalized glucocorticoid Drug Info [1]
Targeted Disease Adrenal incidentalomas
Mutation Info Missense: R477S
Drugs
Drug Name Generalized glucocorticoid Drug Info [1]
Targeted Disease Adrenal incidentalomas
Mutation Info Missense: Y478C
Drugs
Drug Name Generalized glucocorticoid Drug Info [1]
Targeted Disease Adrenal incidentalomas
References
REF 1 Three Novel Heterozygous Point Mutations of NR3C1 Causing Glucocorticoid Resistance.Hum Mutat.2016 Aug;37(8):794-803.

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