| Target General Information |
| Target ID |
T79068
|
| Target Name |
Bacterial Enoyl-[acyl-carrier-protein] reductase [NADH] (Inha) |
| Gene Name |
inhA |
| Species |
Mycobacterium tuberculosis |
| UniProt ID |
INHA_MYCTU |
| Sequence |
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL [Mycobacterium tuberculosis]
|
| Drug and Corresponding Resistance Mutations |
| Mutation Info |
Missense: E217D |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[9] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
1 out of 28 isolates |
|
| Mutation Info |
Missense: I16T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[2], [4] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: I194T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[2], [5] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
52 out of 102 isolates |
|
| Mutation Info |
Missense: I21T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[2], [3] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: I21V |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[2], [3] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: I47T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[2], [4] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: I95P |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[2], [6] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
7 out of 14 isolates |
|
| Drug Name |
Ethionamide |
Drug Info
|
[6] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
7 out of 14 isolates |
|
| Mutation Info |
Missense: I95T |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[7] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: K8N |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: R202G |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[9] |
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
1 out of 28 isolates |
|
| Mutation Info |
Missense: S94A |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[1], [2] |
| Targeted Disease |
Tuberculosis |
|
| Drug Name |
Ethionamide |
Drug Info
|
[1] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: S94L |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[8] |
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: V78A |
| Drugs |
| Drug Name |
Isoniazid |
Drug Info
|
[2], [4] |
| Targeted Disease |
Tuberculosis |
|
| References |
| REF 1 |
Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea. Int J Tuberc Lung Dis. 2000 May;4(5):441-7.
|
| REF 2 |
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
|
| REF 3 |
ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2003 Dec;47(12):3799-805.
|
| REF 4 |
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates. J Infect Dis. 1998 Sep;178(3):769-75.
|
| REF 5 |
Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA. Antimicrob Agents Chemother. 2006 Mar;50(3):1075-8.
|
| REF 6 |
New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains. Lancet. 1995 Aug 19;346(8973):502-3.
|
| REF 7 |
Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis. 1998;79(1):3-29.
|
| REF 8 |
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat Med. 2006 Sep;12(9):1027-9.
|
| REF 9 |
Performance assessment of the GenoType MTBDRplus test and DNA sequencing in detection of multidrug-resistant Mycobacterium tuberculosis. J Clin Microbiol. 2009 Aug;47(8):2520-4.
|
