Target General Information
Target ID T88887
Target Name Bacterial DNA-directed RNA polymerase subunit beta (rpoB)
Gene Name rpoB
Species Mycobacterium tuberculosis
UniProt ID RPOB_MYCTU
Sequence MLEGCILADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDS
FEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVD
ECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLV
RSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKA
LGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLF
FKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGG
VEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINI
RPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHY
GRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHV
VAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHD
DANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITV
MHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLL
VAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEV
LADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVP
HGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILP
VEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLP
DELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFP
YPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYG
AAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSS
DGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA [Mycobacterium tuberc
ulosis]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: A1085V
Drugs
Drug Name Daptomycin Drug Info [37]
Targeted Disease Bacterial infection
Mutation Info Missense: A381V
Drugs
Drug Name Rifampicin Drug Info [27], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1 out of 39 isolates
Mutation Info Missense: A473T
Drugs
Drug Name Rifampicin Drug Info [37]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: A477T
Drugs
Drug Name Rifampicin Drug Info [37]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: A621E
Drugs
Drug Name Daptomycin Drug Info [37]
Targeted Disease Bacterial infection
Mutation Info Missense: D516-Q517
Drugs
Drug Name Rifampicin Drug Info [1]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: D516A
Drugs
Drug Name Rifampicin Drug Info [6]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: D516E
Drugs
Drug Name Rifampicin Drug Info [1]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2% of the patients
Mutation Info Missense: D516F
Drugs
Drug Name Rifampicin Drug Info [24]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: D516G
Drugs
Drug Name Rifampicin Drug Info [24], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: D516H
Drugs
Drug Name Rifampicin Drug Info [11], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 3 out of 46 isolates
Mutation Info Missense: D516K
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: D516N
Drugs
Drug Name Rifampicin Drug Info [16], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: D516T
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: D516V
Drugs
Drug Name Rifampicin Drug Info [1], [4], [5]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1% of the patients
Mutation Info Missense: D516Y
Drugs
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2% of the patients
Mutation Info Missense: E504A
Drugs
Drug Name Rifampicin Drug Info [16], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: E541G
Drugs
Drug Name Rifampicin Drug Info [14], [29]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: E562G
Drugs
Drug Name Rifampicin Drug Info [31]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: E672D
Drugs
Drug Name Rifampicin Drug Info [19], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: F505L
Drugs
Drug Name Rifampicin Drug Info [4], [7], [8]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2 out of 41 isolates
Mutation Info Missense: F505S
Drugs
Drug Name Rifampicin Drug Info [28]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: F514
Drugs
Drug Name Rifampicin Drug Info [2], [1]
Targeted Disease Bacterial infection; Tuberculosis
Drug Name Rifampicin Drug Info [2], [1]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: F514-D516
Drugs
Drug Name Rifampicin Drug Info [2]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: F514L
Drugs
Drug Name Rifampicin Drug Info [26], [27]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1 out of 39 isolates
Mutation Info Missense: F514V
Drugs
Drug Name Rifampicin Drug Info [2]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: F515
Drugs
Drug Name Rifampicin Drug Info [24]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: F632S
Drugs
Drug Name Daptomycin Drug Info [37]
Targeted Disease Bacterial infection
Mutation Info Missense: FM513
Drugs
Drug Name Rifampicin Drug Info [1]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: G507-T508
Drugs
Drug Name Rifampicin Drug Info [6]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: G507D
Drugs
Drug Name Rifampicin Drug Info [4], [11], [12]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2 out of 46 isolates
Mutation Info Missense: G507S
Drugs
Drug Name Rifampicin Drug Info [11], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: G513N
Drugs
Drug Name Rifampicin Drug Info [11]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: G523A
Drugs
Drug Name Rifampicin Drug Info [11]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: G523W
Drugs
Drug Name Rifampicin Drug Info [14], [15]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 37 out of 42 isolates
Mutation Info Missense: H481N
Drugs
Drug Name Rifampicin Drug Info [37]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: H526C
Drugs
Drug Name Rifampicin Drug Info [12], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2 out of 37 isolates
Mutation Info Missense: H526D
Drugs
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 52 out of 128 isolates
Mutation Info Missense: H526E
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: H526F
Drugs
Drug Name Rifampicin Drug Info [11], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: H526G
Drugs
Drug Name Rifampicin Drug Info [6], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: H526L
Drugs
Drug Name Rifampicin Drug Info [1]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2% of the patients
Mutation Info Missense: H526N
Drugs
Drug Name Rifampicin Drug Info [21], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: H526P
Drugs
Drug Name Rifampicin Drug Info [13], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: H526Q
Drugs
Drug Name Rifampicin Drug Info [1], [4], [13]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1% of the isolates
Mutation Info Missense: H526R
Drugs
Drug Name Rifampicin Drug Info [12], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1 out of 37 isolates
Mutation Info Missense: H526S
Drugs
Drug Name Rifampicin Drug Info [29], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 49 out of 54 isolates
Mutation Info Missense: H526T
Drugs
Drug Name Rifampicin Drug Info [6], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: H526Y
Drugs
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 32% of the isolates
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 32% of the isolates
Mutation Info Missense: I561T
Drugs
Drug Name Rifampicin Drug Info [19]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: I561V
Drugs
Drug Name Rifampicin Drug Info [21]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: I572F
Drugs
Drug Name Rifampicin Drug Info [17], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: I953S
Drugs
Drug Name Daptomycin Drug Info [37]
Targeted Disease Bacterial infection
Mutation Info Missense: K527
Drugs
Drug Name Rifampicin Drug Info [2]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: K527N
Drugs
Drug Name Rifampicin Drug Info [9], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: K527Q
Drugs
Drug Name Rifampicin Drug Info [32], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1 out of 110 isolates
Mutation Info Missense: L466S
Drugs
Drug Name Rifampicin Drug Info [37]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: L511M
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: L511P
Drugs
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 3% of the isolates
Mutation Info Missense: L511R
Drugs
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2% of the patients
Mutation Info Missense: L511V
Drugs
Drug Name Rifampicin Drug Info [9], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: L521L
Drugs
Drug Name Rifampicin Drug Info [23]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2 out of 840 isolates
Mutation Info Missense: L521M
Drugs
Drug Name Rifampicin Drug Info [6], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: L521P
Drugs
Drug Name Rifampicin Drug Info [27], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1 out of 39 isolates
Mutation Info Missense: L524S
Drugs
Drug Name Rifampicin Drug Info [10]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: L524W
Drugs
Drug Name Rifampicin Drug Info [2]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: L533P
Drugs
Drug Name Rifampicin Drug Info [2], [3], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 15 out of 258 isolates
Drug Name Rifampicin Drug Info [2], [3], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 15 out of 258 isolates
Mutation Info Missense: L533R
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: L538 STOP
Drugs
Drug Name Rifampicin Drug Info [28]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 101 out of 112 isolates in all rpoB mutations
Mutation Info Missense: L538P
Drugs
Drug Name Rifampicin Drug Info [28], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 101 out of 112 isolates in all rpoB mutations
Mutation Info Missense: L538R
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: L545M
Drugs
Drug Name Rifampicin Drug Info [39]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 4 out of 14 isolates
Mutation Info Missense: L571V
Drugs
Drug Name Rifampicin Drug Info [19], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: M515-N518
Drugs
Drug Name Rifampicin Drug Info [2]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: M515I
Drugs
Drug Name Rifampicin Drug Info [4], [5], [6]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: M515V
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: N518D
Drugs
Drug Name Rifampicin Drug Info [36]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 25 out of 38 isolates in all rpoB mutations
Mutation Info Missense: N518H
Drugs
Drug Name Rifampicin Drug Info [12], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1 out of 37 isolates
Mutation Info Missense: N518I
Drugs
Drug Name Rifampicin Drug Info [22], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: N518T
Drugs
Drug Name Rifampicin Drug Info [9], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: N518Y
Drugs
Drug Name Rifampicin Drug Info [28]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 101 out of 112 isolates in all rpoB mutations
Mutation Info Missense: N519
Drugs
Drug Name Rifampicin Drug Info [8]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2 out of 41 isolates
Mutation Info Missense: N519K
Drugs
Drug Name Rifampicin Drug Info [11], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2 out of 46 isolates
Mutation Info Missense: P535H
Drugs
Drug Name Rifampicin Drug Info [29]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: P535S
Drugs
Drug Name Rifampicin Drug Info [38]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 4 out of 34 isolates
Mutation Info Missense: P564L
Drugs
Drug Name Rifampicin Drug Info [31], [4]
Targeted Disease Bacterial infection; Tuberculosis
Drug Name Rifampicin Drug Info [31], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q465R
Drugs
Drug Name Rifampicin Drug Info [37]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q468K
Drugs
Drug Name Rifampicin Drug Info [37]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q490H
Drugs
Drug Name Rifampicin Drug Info [20], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q510H
Drugs
Drug Name Rifampicin Drug Info [5]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q510K
Drugs
Drug Name Rifampicin Drug Info [10]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 59 out of 409 isolates
Mutation Info Missense: Q513 STOP
Drugs
Drug Name Rifampicin Drug Info [11]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q513-F514
Drugs
Drug Name Rifampicin Drug Info [6]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q513-M516 > H
Drugs
Drug Name Rifampicin Drug Info [6]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q513D
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q513E
Drugs
Drug Name Rifampicin Drug Info [29], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 49 out of 54 isolates
Mutation Info Missense: Q513H
Drugs
Drug Name Rifampicin Drug Info [2]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q513K
Drugs
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1% of the isolates
Mutation Info Missense: Q513L
Drugs
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2% of the patients
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2% of the patients
Mutation Info Missense: Q513P
Drugs
Drug Name Rifampicin Drug Info [12], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2 out of 37 isolates
Drug Name Rifampicin Drug Info [12], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 2 out of 37 isolates
Mutation Info Missense: Q513R
Drugs
Drug Name Rifampicin Drug Info [23], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 17 out of 840 isolates
Mutation Info Missense: Q517
Drugs
Drug Name Rifampicin Drug Info [34]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q517-N518
Drugs
Drug Name Rifampicin Drug Info [22], [1]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q517-N519 > H
Drugs
Drug Name Rifampicin Drug Info [6]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q517H
Drugs
Drug Name Rifampicin Drug Info [30], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 97 out of 148 isolates
Mutation Info Missense: Q517L
Drugs
Drug Name Rifampicin Drug Info [5], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: Q961K
Drugs
Drug Name Daptomycin Drug Info [37]
Targeted Disease Bacterial infection
Mutation Info Missense: R484H + E517Q
Drugs
Drug Name Rifampicin Drug Info [41]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: R515
Drugs
Drug Name Rifampicin Drug Info [20]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: R528H
Drugs
Drug Name Rifampicin Drug Info [9], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: R528P
Drugs
Drug Name Rifampicin Drug Info [4], [9], [10]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: R529C
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: R529Q
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: R529S
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: R633C
Drugs
Drug Name Rifampicin Drug Info [19]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: R687H
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S450L
Drugs
Drug Name Rifampicin Drug Info [40]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S456L
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S509Q
Drugs
Drug Name Rifampicin Drug Info [10], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S509R
Drugs
Drug Name Rifampicin Drug Info [25], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S509T
Drugs
Drug Name Rifampicin Drug Info [32]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1 out of 110 isolates
Mutation Info Missense: S512G
Drugs
Drug Name Rifampicin Drug Info [36]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 25 out of 38 isolates in all rpoB mutations
Mutation Info Missense: S512I
Drugs
Drug Name Rifampicin Drug Info [5], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S512R
Drugs
Drug Name Rifampicin Drug Info [6], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S512T
Drugs
Drug Name Rifampicin Drug Info [1], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1% of the isolates
Mutation Info Missense: S522L
Drugs
Drug Name Rifampicin Drug Info [13], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S522Q
Drugs
Drug Name Rifampicin Drug Info [17], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S522W
Drugs
Drug Name Rifampicin Drug Info [23], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S531C
Drugs
Drug Name Rifampicin Drug Info [6], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S531F
Drugs
Drug Name Rifampicin Drug Info [22], [4]
Targeted Disease Bacterial infection; Tuberculosis
Drug Name Rifampicin Drug Info [22], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S531G
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S531L
Drugs
Drug Name Rifampicin Drug Info [33], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 1 out of 7 isolates
Mutation Info Missense: S531Q
Drugs
Drug Name Rifampicin Drug Info [6]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S531W
Drugs
Drug Name Rifampicin Drug Info [13], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S531Y
Drugs
Drug Name Rifampicin Drug Info [13]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S553A
Drugs
Drug Name Rifampicin Drug Info [14]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: S574L
Drugs
Drug Name Rifampicin Drug Info [36], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 25 out of 38 isolates in all rpoB mutations
Mutation Info Missense: S622A
Drugs
Drug Name Rifampicin Drug Info [29]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: T508A
Drugs
Drug Name Rifampicin Drug Info [11]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 35 out of 46 isolates
Mutation Info Missense: T508H
Drugs
Drug Name Rifampicin Drug Info [11]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 35 out of 46 isolates
Mutation Info Missense: T508P
Drugs
Drug Name Rifampicin Drug Info [11]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Prevalence 35 out of 46 isolates
Mutation Info Missense: T508S
Drugs
Drug Name Rifampicin Drug Info [34], [35]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: T525I
Drugs
Drug Name Rifampicin Drug Info [14]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: T525P
Drugs
Drug Name Rifampicin Drug Info [2]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: T563P
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: V146F
Drugs
Drug Name Rifampicin Drug Info [18], [4]
Targeted Disease Bacterial infection; Tuberculosis
Drug Name Rifampicin Drug Info [18], [4]
Targeted Disease Bacterial infection; Tuberculosis
Mutation Info Missense: V472I
Drugs
Drug Name Rifampicin Drug Info [4]
Targeted Disease Bacterial infection; Tuberculosis
References
REF 1 Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas. J Clin Microbiol. 1994 Apr;32(4):1095-8.
REF 2 Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from Brazil. J Clin Microbiol. 2000 Aug;38(8):3119-22.
REF 3 Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. Antimicrob Agents Chemother. 1996 Nov;40(11):2655-7.
REF 4 CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
REF 5 Molecular characterization of rifampin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Poland. J Clin Microbiol. 2004 Jun;42(6):2425-31.
REF 6 Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis. 1998;79(1):3-29.
REF 7 In-depth molecular characterization of Mycobacterium tuberculosis from New Delhi--predominance of drug resistant isolates of the 'modern' (TbD1) type. PLoS One. 2009;4(2):e4540.
REF 8 Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study. Lancet. 1994 Jul 30;344(8918):293-8.
REF 9 Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India. Antimicrob Agents Chemother. 2002 Feb;46(2):443-50.
REF 10 Mutations in rpoB and katG genes in Mycobacterium isolates from the Southeast of Mexico. Mem Inst Oswaldo Cruz. 2009 May;104(3):468-72.
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