Target General Information
Target ID	T91001
Target Name	Bacterial Elongation factor Tu (EF-Tu)
Gene Name	EF-Tu
Species	Peptoclostridium difficile
UniProt ID	EFTU_PEPD6
Sequence	MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGEAVDFANIDKAPEERER GITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSATDGPMPQTREH ILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLTEYDFPGDDTPIVRGSALMAL EDPKSEWGDKIVELFEQIDEYIPAPERDTDKPFLMPVEDVFSITGRGTVATGRVERGVLK VQDEVELVGLTEAPRKVVVTGVEMFRKLLDQAQAGDNIGALLRGVQRNEIERGQVLAKTG SVKAHTKFTAEVYVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGACKLPEGIEMVMPGDNV TMEVDLINSIVVEEGLRFSIREGGRTVASGVVATIIE [Peptoclostridium diff icile]
Drug and Corresponding Resistance Mutations
Mutation Info	Missense: A376S
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: A376V
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: E379K
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: G261E
Drugs	Drug Name Elfamycin Drug Info [2]
Mutation Info	Missense: G317D
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: L121Q
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: Q125E
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: Q125K
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: Q125R
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: R231C
Drugs	Drug Name Pulvomycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: R231V
Drugs	Drug Name Pulvomycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: R234F
Drugs	Drug Name Pulvomycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: R234S
Drugs	Drug Name Pulvomycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: R334C
Drugs	Drug Name Pulvomycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: T335A
Drugs	Drug Name Pulvomycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: Y161C
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: Y161D
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
Mutation Info	Missense: Y161N
Drugs	Drug Name Kirromycin Drug Info [1] Targeted Disease Bacterial infection
References
REF 1	CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
REF 2	The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57.

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